SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Introduction to modern chemistry and technology of peptides - D342009
Title: Úvod do moderní chemie a technologie peptidů
Guaranteed by: Department of Chemistry of Natural Compounds (342)
Actual: from 2015
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 0/0 other [hours/week]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Flegel Martin RNDr. CSc.
Is interchangeable with: AP342003, P342003
Annotation -
Last update: TAJ342 (30.03.2014)
Amino acids (AA), their codes and basic properties. AA derivatives, orthogonally protected and their utilization in peptide synthesis in solution. Coupling agents and some side reaction, occurring during condensation. Some other synthetic difficulties in peptide synthesis. Examples of peptide preparation. Peptides used as therapeutics and their production. Survey of the chosen peptides - active pharmaceutical ingredients (API). Basic principles of solid phase synthesis. Paralell synthesis, robotics, and construction of the libraries. Utilization of combinatorial chemistry and future of peptides.
Aim of the course -
Last update: TAJ342 (31.03.2014)

Students will be able to

describe methods of preparation of synthetic peptides by various classical and modern procedures

Describe basic methods of their analysis and technology of production

View peptides as a group of natural compounds with a chance of their structural modifications with respect to biological and pharmacological properties and further utilization in medicine

Literature -
Last update: TAJ342 (30.03.2014)

1. (Z) Jones J.: Amino Acid and Peptide Synthesis: Oxford University Press New York, 2002.

2. (D) Grant A.G.: Synthetic Peptides A Users Guide (second edition) : 2002 Oxford University Press.

3. (D) Keith ó Proinsias: Short Peptide Synthesis (http://ww2.icho.edu.pl/Gryko_group/data/seminars/peptide.pdf).

Learning resources -
Last update: TAJ342 (31.03.2014)

None

Syllabus -
Last update: TAJ342 (30.03.2014)

1. Amino acids (AA)

2. Protecting groups: protection of amino and α-carboxylic groups. Tactics for protection of amino acids side chains.

3. Coupling alternatives in carboxylic group activation, frequently used coupling agents, methods of condensation of AA derivatives, interesting and frequent side reactions.

4. Other methods of amide bond formation, chemical ligation and use of enzymes for peptide synthesis.

5. Examples of peptide synthesis in solution, analysis, and commercial peptide production.

6. Peptide drugs: biological properties of chosen peptide, production methods - their limits and advantages, survey of the main peptide pharmaceuticals.

7. Solid phase peptide synthesis concept.

8. Automatic peptide synthesis and design of the synthesizers.

9. Parallel peptide synthesis.

10. Combinatorial chemistry history.

11. Libraries preparation and their use for discovery of new materials and pharmaceuticals.

12. Use of peptide and small molecule libraries.

13. Future of peptides

Registration requirements -
Last update: TAJ342 (31.03.2014)

None

Coursework assessment
Form Significance
Regular attendance 30
Oral examination 70

 
VŠCHT Praha