SubjectsSubjects(version: 941)
Course, academic year 2023/2024
Thermodynamics and kinetics of pharmaceutical systems - M111021
Title: Termodynamika a kinetika farmaceutických systémů
Guaranteed by: Department of Organic Technology (111)
Faculty: Faculty of Chemical Technology
Actual: from 2022
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1, C+Ex [HT]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
For type:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Školáková Tereza Ing. Ph.D.
This subject contains the following additional online materials
Annotation -
Last update: Školáková Tereza Ing. Ph.D. (03.05.2022)
The course covers basic aspects of physical chemistry, which are used in drug research and production, and further deepens knowledge of state behavior and thermodynamic properties of pure liquids and solids, thermodynamic description of condensed solutions, phase and chemical equilibria in heterogeneous systems, physical chemistry of surfaces and phase interfaces. and macrokinetic description of phase transformations and chemical reactions. There is also a section devoted to the influence of the size and shape of nanostructured materials on their physical and chemical properties, which is one of the modern trends in recent years in drug development. The content of the course is mainly focused on pharmaceutically important substances and systems and processes commonly used in the manufacture of drugs.
Aim of the course -
Last update: Školáková Tereza Ing. Ph.D. (03.05.2022)

Students will be able to:

Derive and explain basic thermodynamic relations.

Interpret phase diagrams of different systems.

Understand the principles of phase transformations.

Solve problems related to the processes and events at phase interfaces.

Literature -
Last update: Školáková Tereza Ing. Ph.D. (03.05.2022)

1. Connors, K. A., Mecozzi, S. (2010). Thermodynamics of pharmaceutical systems: An introduction to theory and applications. John Wiley & Sons. ISBN: 978-0-470-56751-7

2. Leitner, J., Sedmidubský, D., Voňka, P. (2019) Termodynamika materiálů (skripta VŠCHT), 2. vydání, VŠCHT Praha. ISBN: 978-80-7592-045-4

3. Otto, D. P., de Villiers, M. M. (2009). Physicochemical principles of nanosized drug delivery systems. In Nanotechnology in drug delivery (pp. 3-33). Springer, New York, NY. ISBN: 978-0-387-77668-2

Syllabus -
Last update: Školáková Tereza Ing. Ph.D. (03.05.2022)

1. Basic thermodynamic terminology and principles

2. Structure and bonding in solids

3. State behaviour of liquids and solids

4. Thermodynamic functions of pure liquids and solids

5. Thermodynamic concept of equilibrium

6. Phase transformations phase equilibria in single-component systems

7. Chemical transformations with the participation of pure liquids and solids

8. Thermodynamics of solutions

9. Phase and chemical equilibria with the participation of liquid and solid solutions

10. Surfaces and phase interfaces

11. Porosity of solid materials.

12. Kinetics of chemical and phase transformations

13. Influence of particles size and shape on the properties of solids

14. Heterogeneous dispersions

Registration requirements -
Last update: Školáková Tereza Ing. Ph.D. (03.05.2022)

Physical Chemistry I

Course completion requirements -
Last update: Školáková Tereza Ing. Ph.D. (03.05.2022)

Acquiring credit for solving examples of the computational part.

Successful completion of the test (at least 40%) and passing the oral exam.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0.5 14
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0.5 14
Příprava na zkoušku a její absolvování 1.5 42
Účast na seminářích 0.5 14
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