SubjectsSubjects(version: 953)
Course, academic year 2023/2024
Biopharmaceuticals - M320021
Title: Bioléčiva
Guaranteed by: Department of Biochemistry and Microbiology (320)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2023
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Fusek Martin prof. Ing. CSc.
Benešová Eva Ing. Ph.D.
This subject contains the following additional online materials
Annotation -
The subject "Biopharmaceuticals" is dedicated to a general description of rapidly developing field of pharmaceutical industry to the students. Main drugs produced by conventional biotechnological processes (antibiotics, alkaloids, etc.) will be mentioned in an abbreviated form and then recombinant technologies, which are used for the production of biodrugs, will be explained. In the general part of the course, attention will be paid to the differences in the production of small molecules and proteins, after that different types of biodrugs, their indications and functions in the human body, and pathology will be discussed. Students also have to prepare their own presentations on given topics.
Last update: Hladíková Jana (13.12.2017)
Aim of the course -

Students will get knowledge of

• basic processes for recombinant pharmaceuticals production

• main types of indications and pathologies in which biodrugs are applied

• main representatives = particular biodrugs

Last update: Benešová Eva (15.09.2023)
Literature -

R:Fusek M., Káš J., Ruml T., Bioléčiva � VŠCHT Praha, 2008, 9788070806784

A:Fusek M., Vitek L, Blahos J., Hajdúch M., Ruml T., Biologická léčiva - teoretické základy a klinická praxe, GRADA, 2012, 9788024737270

A: Walsh G., Biopharmaceuticals - biochemistry and biotechnology, Wiley, 2003, 0470843268

Last update: Hladíková Jana (13.12.2017)
Learning resources -

Lectures in electronic form published at

Dictionary of Biopharmaceuticals and Fundamentals of Human Pathology available at

Last update: Benešová Eva (16.09.2023)
Requirements to the exam - Czech

Předmět je zakončen písemnou a ústní zkouškou.

Last update: Benešová Eva (15.09.2023)
Syllabus -

1. Biopharmaceuticals, history and the content of the subject

2. Biomacromolecules - structure, posttranslational modifications

3. Biomacromolecules - function

4. Analysis of biomacromolecules - methodology

5. Organisms used for biodrugs production and cell biology

6. Methods of fermentation - animal cell lines, genetic modifications

7. Isolation procedures - methodology

8. Overview of main biodrugs - monoclonal antibodies

9. Overview of main biodrugs - proteins and enzymes replacement therapy

10. Proteins and enzymes replacement therapy

11. Overview of main biodrugs -vaccines

12. Overview of main biodrugs - expression regulation and future prospects

13. Biodrugs safety and quality control

14. Commercial aspects - overview of main manufacturers and sales

Last update: Kubová Petra (02.07.2023)
Registration requirements -

Biochemistry (Biochemistry I)

Molecular Genetics

Last update: Hladíková Jana (13.12.2017)
Course completion requirements - Czech

Předmět je zakončen písemnou a ústní zkouškou.

Last update: Benešová Eva (15.09.2023)
Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na zkoušku a její absolvování 2 56
3 / 3 84 / 84
Coursework assessment
Form Significance
Examination test 50
Oral examination 50