SubjectsSubjects(version: 863)
Course, academic year 2019/2020
Biopharmaceuticals - M320021
Title: Bioléčiva
Guaranteed by: Department of Biochemistry and Microbiology (320)
Actual: from 2019
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Is provided by: N320067
For type: Master's (post-Bachelor)
Guarantor: Benešová Eva Ing. Ph.D.
Fusek Martin prof. Ing. CSc.
Interchangeability : N320067
Annotation -
Last update: Hladíková Jana (13.12.2017)
The subject "Biopharmaceuticals" is dedicated to a general description of rapidly developing field of pharmaceutical industry to the students. Main drugs produced by conventional biotechnological processes (antibiotics, alkaloids, etc.) will be mentioned in an abbreviated form and then recombinant technologies, which are used for the production of biodrugs, will be explained. In the general part of the course, attention will be paid to the differences in the production of small molecules and proteins, after that different types of biodrugs, their indications and functions in the human body, and pathology will be discussed. Students also have to prepare their own presentations on given topics.
Aim of the course -
Last update: Hladíková Jana (13.12.2017)

Students will get knowledge of

• basic processes for recombinant pharmaceuticals production

• basic analytical procedures

• main types of indications and pathologies in which biodrugs are applied

• main representatives = particular biodrugs

Literature -
Last update: Hladíková Jana (13.12.2017)

R:Fusek M., Káš J., Ruml T., Bioléčiva � VŠCHT Praha, 2008, 9788070806784

A:Fusek M., Vitek L, Blahos J., Hajdúch M., Ruml T., Biologická léčiva - teoretické základy a klinická praxe, GRADA, 2012, 9788024737270

A: Walsh G., Biopharmaceuticals - biochemistry and biotechnology, Wiley, 2003, 0470843268

Learning resources -
Last update: Hladíková Jana (13.12.2017)

Syllabus -
Last update: Kubová Petra Ing. (23.02.2018)

1. Biopharmaceuticals, history and the content of the subject

2. Biomacromolecules - structure, posttranslational modifications

3. Biomacromolecules - function

4. Analysis of biomacromolecules - methodology

5. Organisms used for biodrugs production and cell biology

6. Methods of fermentation - animal cell lines, genetic modifications

7. Isolation procedures - methodology

8. Overview of main biodrugs - monoclonal antibodies

9. Overview of main biodrugs - proteins and enzymes replacement therapy

10. Proteins and enzymes replacement therapy

11. Overview of main biodrugs -vaccines

12. Overview of main biodrugs - expression regulation and future prospects

13. Biodrugs safety and quality control

14. Commercial aspects - overview of main manufacturers and sales

Registration requirements -
Last update: Hladíková Jana (13.12.2017)

Biochemistry (Biochemistry I)

Molecular Genetics

Course completion requirements - Czech
Last update: Fusek Martin prof. Ing. CSc. (15.01.2018)

Student musí úspěšně absolvovat závěrečný test a poté absolvovat úspěšně ústní zkoušku.

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na zkoušku a její absolvování 2 56
3 / 3 84 / 84
Coursework assessment
Form Significance
Examination test 25
Oral examination 75