SubjectsSubjects(version: 898)
Course, academic year 2021/2022
  
Biopharmaceuticals - M320021
Title: Bioléčiva
Guaranteed by: Department of Biochemistry and Microbiology (320)
Actual: from 2020
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: Master's (post-Bachelor)
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Fusek Martin prof. Ing. CSc.
Benešová Eva Ing. Ph.D.
Interchangeability : N320067
This subject contains the following additional online materials
Annotation -
Last update: Hladíková Jana (13.12.2017)
The subject "Biopharmaceuticals" is dedicated to a general description of rapidly developing field of pharmaceutical industry to the students. Main drugs produced by conventional biotechnological processes (antibiotics, alkaloids, etc.) will be mentioned in an abbreviated form and then recombinant technologies, which are used for the production of biodrugs, will be explained. In the general part of the course, attention will be paid to the differences in the production of small molecules and proteins, after that different types of biodrugs, their indications and functions in the human body, and pathology will be discussed. Students also have to prepare their own presentations on given topics.
Aim of the course -
Last update: Hladíková Jana (13.12.2017)

Students will get knowledge of

• basic processes for recombinant pharmaceuticals production

• basic analytical procedures

• main types of indications and pathologies in which biodrugs are applied

• main representatives = particular biodrugs

Literature -
Last update: Hladíková Jana (13.12.2017)

R:Fusek M., Káš J., Ruml T., Bioléčiva � VŠCHT Praha, 2008, 9788070806784

A:Fusek M., Vitek L, Blahos J., Hajdúch M., Ruml T., Biologická léčiva - teoretické základy a klinická praxe, GRADA, 2012, 9788024737270

A: Walsh G., Biopharmaceuticals - biochemistry and biotechnology, Wiley, 2003, 0470843268

Learning resources -
Last update: Hladíková Jana (13.12.2017)

www.sciencedirect.com

Syllabus -
Last update: Kubová Petra Ing. (23.02.2018)

1. Biopharmaceuticals, history and the content of the subject

2. Biomacromolecules - structure, posttranslational modifications

3. Biomacromolecules - function

4. Analysis of biomacromolecules - methodology

5. Organisms used for biodrugs production and cell biology

6. Methods of fermentation - animal cell lines, genetic modifications

7. Isolation procedures - methodology

8. Overview of main biodrugs - monoclonal antibodies

9. Overview of main biodrugs - proteins and enzymes replacement therapy

10. Proteins and enzymes replacement therapy

11. Overview of main biodrugs -vaccines

12. Overview of main biodrugs - expression regulation and future prospects

13. Biodrugs safety and quality control

14. Commercial aspects - overview of main manufacturers and sales

Registration requirements -
Last update: Hladíková Jana (13.12.2017)

Biochemistry (Biochemistry I)

Molecular Genetics

Course completion requirements - Czech
Last update: Fusek Martin prof. Ing. CSc. (15.01.2018)

Student musí úspěšně absolvovat závěrečný test a poté absolvovat úspěšně ústní zkoušku.

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na zkoušku a její absolvování 2 56
3 / 3 84 / 84
 
VŠCHT Praha