SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Chemistry of Saccharides and Biopolymers - M342010
Title: Chemie sacharidů a biopolymerů
Guaranteed by: Department of Chemistry of Natural Compounds (342)
Actual: from 2019
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Šimák Ondřej Ing. Ph.D.
Interchangeability : N342013
Annotation -
Last update: Fialová Jana (20.12.2017)
The course is aimed at understanding of physical, chemical and biological properties of saccharides as a group of organic compounds important for living organisms. It covers also an overview of basic transformations of monosaccharides to their most important derivatives. It gives an overview of oligo- and polysaccharides together with their occurrence in nature and potential application as new raw materials for pharmaceutical and food industry.
Aim of the course -
Last update: Fialová Jana (20.12.2017)

Students will be able to:

Design synthetic strategies for modification of polyfunctional molecules

Have an overview of stereochemistry of chiral compounds

Literature -
Last update: Fialová Jana (20.12.2017)

R: Boons G.J. (red.), Carbohydrate Chemistry, Blackie 1998.

R: Steglich W., et al. (red.), Natural Products, Thieme 2000.

Learning resources -
Last update: Fialová Jana (20.12.2017)

Lecture notes

Syllabus -
Last update: Fialová Jana (20.12.2017)

1. Importance of saccharides in nature, building and storage saccharides, recognition at cellular level

2. Stereochemistry of saccharides, mutarotation, formulae, basics of nomenclature

3. Manipulations with polyfunctional molecule, protecting groups, deprotection

4. Preparation and importance of glycosides

5. Alkylation, acylation, oxidation, reduction, regioselectivity of reactions

6. Nucleophilic substitution, activation of hydroxy groups

7. Synthesis of derivatives (oxirans, anhydro and amino sugars, glycosyl halogenides)

8. Thio saccharides, thio glycosides, occurrence in nature, synthesis

9. Overview of important oligosaccharides, their properties and modification

10. Overview of important polysaccharides, their properties and modification

11. Biotransformations in synthesis of saccharide derivatives

12 Methods of preparation of branched saccharides

13. N- and C-glycosides

14. Practical experience with synthesis of polyfunctional compounds, rational design of compounds with potential biological activity

Registration requirements -
Last update: Fialová Jana (20.12.2017)

Organic chemistry I

Coursework assessment
Form Significance
Regular attendance 40
Oral examination 60

 
VŠCHT Praha