SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Techniques of Measurement and Interpretation of NMR Spectra - M402012
Title: Techniky měření a interpretace NMR spekter
Guaranteed by: Department of Analytical Chemistry (402)
Actual: from 2019
Semester: winter
Points: winter s.:2
E-Credits: winter s.:2
Examination process: winter s.:
Hours per week, examination: winter s.:1/0 Ex [hours/week]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Additional information: http://www.vscht.cz/anl/dolensky/technmr/index.html
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Dolenský Bohumil doc. Ing. Ph.D.
Interchangeability : N402032
Annotation -
Last update: Pátková Vlasta (05.01.2018)
The course focuses on detailed interpretation of 1D and 2D NMR spectra, and their relationships with the structure of organic compounds.
Aim of the course -
Last update: Pátková Vlasta (05.01.2018)

Students will be able to:

In detail interpret 1D and 2D NMR spectra (in particular 1H, 19F, 13C, 31P, 15N, APT, HOMODEC, NOE, NOEDIF, NOESY1D, 2D NOESY, 2D HMBC, 2D HSQC, 2D COSY, 2D TOCSY, ...), and based on a combination of the uniquely assign signals to the atoms in the molecule, or to propose a structure of unknown substance.

Literature -
Last update: Pátková Vlasta (05.01.2018)

A: Holík: Čtyři lekce z NMR, Univerzita J. E. Purkyně, 1987

A: Hollerton: Essential Practical NMR for Organic Chemistry, Kindle Edition, 2011.

Learning resources -
Last update: Pátková Vlasta (05.01.2018)

Web: http://www.vscht.cz/anl/dolensky/technmr/index.html

Teaching methods -
Last update: Pátková Vlasta (05.01.2018)

Lessons

Syllabus -
Last update: Pátková Vlasta (05.01.2018)

1. NMR spectrometer, the origin of NMR signal, the basic parameters of the NMR spectra

2. Chemical and magnetic equivalency of cores, dynamic NMR

3. The multiplicity of signals, interaction 1H-1H

4. Techniques for the measurement and interpretation of 1H NMR spectra

5. Homonuclear decoupling, J-resolved, COSY, LR COSY and TOCSY

6. Nuclear Overhauser effect, NOEDIF, 1D and 2D NOESY, ROESY

7. Heteronuclear interactions, 1H, 13C, 31P, 19F, 2H and 15N

8. 13C NMR spectra, isotopomers

9. Techniques for the measurement and interpretation of the 13C NMR spectra, 1H decoupling, ATP, DEPT

10. Measurement and interpretation of 2D 1H-13C gHSQC

11. Measurement and interpretation of 2D 1H-13C gHMBC

12. Superposition information from NMR experiments

13. Interpretation of spectra of known substances, prediction of NMR spectra

14. Identification of unknown substances from NMR spectra

Registration requirements -
Last update: Pátková Vlasta (05.01.2018)

Knowledge of the fundamental relationships between the structure of organic compounds and its 1H and 13C NMR spectra.

Teaching methods
Activity Credits Hours
Účast na přednáškách 0,5 14
Příprava na zkoušku a její absolvování 1,5 42
2 / 2 56 / 56
Coursework assessment
Form Significance
Examination test 25
Oral examination 75

 
VŠCHT Praha