SubjectsSubjects(version: 873)
Course, academic year 2019/2020
  
Bioinorganic Chemistry - N101025
Title: Bioanorganická chemie
Guaranteed by: Department of Inorganic Chemistry (101)
Actual: from 2014
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: 10 / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course can be enrolled in outside the study plan
Guarantor: Hoskovcová Irena Ing. CSc.
This subject contains the following additional online materials
Annotation -
Last update: TAJ101 (03.12.2013)
The course is based on the Coordination chemistry course. It is aimed at the role of metals in both electron and mass transfers in living systems. It describes the behaviour of individual metals focusing on the relationship between their chemical properties and biological activity, toxicity and therapeutic use.
Aim of the course -
Last update: TAJ101 (03.12.2013)

Students will be able to:

Describe the chemical nature of metal biological activity

Describe the role of biogenic metals in metabolism

Explain toxicity or therapeutical use of non-biogenic metals

Evaluate suitable use of analytical methods in order to study metal ions in biological systems

Literature -
Last update: TAJ101 (26.08.2013)

R: R. R. Crichton, Biological Inorganic Chemistry, 2nd ed., Elsevier 2011, ISBN: 978-0-444-53782-9

A: R. M. Roat-Malonee, Bioinorganic Chemistry, Wiley 2002, ISBN 0-471-15976-X

Learning resources -
Last update: TAJ101 (17.09.2013)

http://vydavatelstvi.vscht.cz/knihy/uid_es-002/

http://www.vscht.cz/ach/vyuka-magisterske-koordch.html ¨

Requirements to the exam -
Last update: TAJ101 (02.09.2013)

Students write a test and pass an oral examination.

Syllabus -
Last update: TAJ101 (02.09.2013)

1. Formal oxidation states and coordination stereochemistry of biologically important metals

2. Stability constants, kinetics and reaction mechanisms of metal complexes

3. Metal ions uptake and their transmembrane flow

4. Metal transport and storage in vivo

5. Myoglobin and haemoglobin. Haemerythrin, haemocyanin.

6. Hydrolysis, carboxypeptidase A, phosphates, hydrolyases, aconitase.

7. Cofactores and coenzymes in redox metalloproteins

8. Iron and sulphur containing clusters, haem.

9. Cupper ions and their complexes

10. Molybdenum, cobalamines, nickel-containing coenzymes

11. Electron-transfer in mitochondria

12. Overview of the 1st and 2nd group metals role in biological systems

13. Enzyme activation, complexes with nucleic acids, biominerals, skeleton.

14. Oxygen toxicity, metal toxicity. Coordination compounds in therapy and diagnostics.

Registration requirements -
Last update: TAJ101 (02.09.2013)

General and Inorganic chemistry II, Biochemistry

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0,5 14
Práce na individuálním projektu 0,5 14
Příprava na zkoušku a její absolvování 1 28
3 / 3 84 / 84
Coursework assessment
Form Significance
Regular attendance 10
Defense of an individual project 20
Examination test 20
Oral examination 50

 
VŠCHT Praha