SubjectsSubjects(version: 853)
Course, academic year 2019/2020
  
Toxicology for Chemists - N110028
Title: Toxikologie pro chemiky
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: 25 / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Linhart Igor doc. Ing. CSc.
Annotation -
Last update: Cibulka Radek prof. Ing. Ph.D. (28.11.2013)
The aim of the subject is to prepare students of chemistry for proper handling the risks of intoxication connected to the chemist´s work and to give them an insight into the science of toxicology needed for their professional carrier in the interdisciplinary fields, where both chemistry and toxicology play an important role. Chemical aspects of the mechanisms of toxicity are emphasised.
Aim of the course -
Last update: Cibulka Radek prof. Ing. Ph.D. (19.08.2013)

Students will be able to:

explain fundamental toxicological terms

perform literature searches within the literature of chemical toxicology

interpret toxicological data

propose plausible metabolic pathways for simple xenobiotics

understand relations between chemical structure, metabolic activation and toxicity

Literature -
Last update: Linhart Igor doc. Ing. CSc. (12.09.2018)

R: S. E. Manahan: Toxicological Chemistry and Biochemistry. 3rd edition, Lewis Publishers 2003; ISBN:1-56670-618-1; available at http://gtu.ge/Agro-Lib/Toxicological_Chemistry_and_Biochemistry__Third_Edition.pdf

A: Lu's Basic Toxicology. Funadamentals, Target Organs, and Risk Assessment. S. Kacew, B.-M. Lee, editors, 6th edition, CRCPress 2012; ISBN: 13:978-1-841849539; 10:978-1-841849537; available at http://www.ssu.ac.ir/cms/fileadmin/user_upload/Moavenatha/MBehdashti/TebKar/PDFs/Lu%E2%80%99s_Basic_Toxicology.pdf

A: J. McMurry, T. Begley: The Organic Chemistry of Biological Pathways. Roberts and Co. Publ., Englewood, Colorado 2005; ISBN 0-9749077-1-6

Learning resources -
Last update: Linhart Igor doc. Ing. CSc. (11.07.2013)

NML Toxicology Tutorials, Parts I and II: http://sis.nlm.nih.gov/enviro/toxtutor.html

Syllabus -
Last update: Linhart Igor doc. Ing. CSc. (17.08.2016)

1. Toxicology, toxicity, definition of the terms, the position of toxicology among other sciences, its brief history.

2. Deleterious effects, mechanisms of toxicity: Xenobiotics and their interactions with living organisms, toxicity at molecular, cellular and organ level.

3. Fate of xenobiotics in the organism: Absorption, distribution, biotransformation and excretion (kinetics of elimination).

4. Xenobiotic biotransformation and toxicity: Types of biotransforming reactions, detoxication and metabolic activation, biotransforming enzymes.

5. Toxic effects and symptoms. Intoxication, types toxicity (acute and chronic, local and systemic, neurotoxicity, immunotoxicity, mutagenicity, teratogenicity, carcinogenicity, organ toxicity.

6. How to assess toxicity. Experiments at molecular, subcellular, cellular, organ and whole body level; computer modelling.

7. Sources of toxicological information:toxikological data (LD, LC, NOAEL, LOAEL, etc.), toxikological data bases, MSDS.

8. Predictive toxicology (SAR, QSAR). Chemical structure based assessment of toxicity.

9. Biological monitoring. Indicators of dose and effect (metabolites, adducts with proteins and DNA).

10. Experimental toxicology: chemical view (what is happening to the xenobiotic) a biological view (what is happening to the living organism).

11. Target and non-target organ toxicity: hepatotoxicity, nephrotoxicity, pneumotoxicity, haematotoxicity, immunotoxicity, cardiotoxicity)

12. Neurotoxicity. Nervous system, its composition, functions and disfunctions; compounds damiging the neuron structure, information transport, psychoactive substances.

13. Carcinogenicity and carcinogens: karcinogenesis, genotoxic and epigenetic carcinogens, structure and biotransformation based assessment of carcinogenicity.

14. Occupational and environmental toxicants. Risk assessment.

Entry requirements -
Last update: Linhart Igor doc. Ing. CSc. (11.07.2013)

Basic knowledge of chemistry (organic and inorganic) and biochemistry.

Registration requirements -
Last update: Linhart Igor doc. Ing. CSc. (11.07.2013)

Organic Chemistry I (or alternatively Organic Chemistry A), Biochemistry

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0,5 14
Příprava na zkoušku a její absolvování 1,5 42
3 / 3 84 / 84
Coursework assessment
Form Significance
Examination test 30
Oral examination 70

 
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