SubjectsSubjects(version: 847)
Course, academic year 2018/2019
  
Biomolecular Interactions - N143047
Title in English: Interakce biomolekul
Guaranteed by: Department of Informatics and Chemistry (143)
Actual: from 2013
Semester: summer
Points: summer s.:3
E-Credits: summer s.:3
Examination process: summer s.:
Hours per week, examination: summer s.:2/0 Ex [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Guarantor: Vondrášek Jiří RNDr. CSc.
This subject contains the following additional online materials
Annotation -
Last update: TAJ143 (03.12.2013)
During the course basic concept of interactions between biomolecules (proteins, nucleic acids, and small ligands) are explained. The main focus of the lectures will be on noncovalent interactions. Theoretical methods of their description, such as e.g. phenomenological potentials and their applications will be explained. Students will further gain knowledge of the design of protein-protein, protein-NA or protein-ligand interactions.
Aim of the course -
Last update: ROZ143 (06.08.2013)

Students will be able to:

  • Understand physico-chemical principles of noncovalent interactions.
  • Know categories of biomolecular interactions.
  • Understand basic statistical and computational tools for working with biomolecular interactions.
  • Master basic concepts of phenomenological potentials.
  • Predict interactions between biomolecules.
Literature -
Last update: ROZ143 (06.08.2013)

R: Jin Xiong, Essential Bioinformatics, Cambridge University Press 2006, ISBN: 978-0-521-60082-8

R: Peter Schuck (ed.), Protein Interactions, Springer 2007, ISBN: 0-387-35965-6

Learning resources -
Last update: ROZ143 (06.08.2013)

none

Syllabus -
Last update: ROZ143 (06.08.2013)

1. Biomolecular interactions - basic concepts

2. Quaternary structure of proteins and its modelling.

3. Interactions between proteins and nucleic acids.

4. Potential energy surface and its construction.

5. Docking algorithms I - principles.

6. Docking algorithms I - oveview of common approaches.

7. Docking protocols.

8. CAPRI.

9. Protein Structure Initiative and computational proteomics.

10. Design of protein-protein interactions.

11. Targeted increase of biomolecular affinity.

12. Rational design of the specificity regulation.

13. Interactome

14. Interaction networks and their construction.

Registration requirements -
Last update: ROZ143 (07.08.2013)

Biochemistry

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Příprava na zkoušku a její absolvování 1 28
3 / 3 84 / 84
Coursework assessment
Form Significance
Examination test 100

 
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