SubjectsSubjects(version: 947)
Course, academic year 2023/2024
Case Studies in Bioinformatics - N143051
Title: Případové studie z bioinformatiky
Guaranteed by: Department of Informatics and Chemistry (143)
Faculty: Faculty of Chemical Technology
Actual: from 2021
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Is provided by: M143006
For type:  
Guarantor: Pačes Jan Mgr. Ph.D.
Is interchangeable with: M143006
Examination dates   Schedule   
Annotation -
Last update: ROZ143 (09.08.2013)
This course summarizes acquired bioinformatics knowledge, and puts bioinformatics skills into a context. Lecturers will demonstrate individual methods and approaches using well documented and well performed experiments. Possible solutions will be compared, and their efficiency will be discussed.
Aim of the course -
Last update: TAJ143 (03.12.2013)

Students will be able to:

  • Gain general knowledge of bioinformatics methods and approaches employed in solving real-life scientific projects.

Literature -
Last update: TAJ143 (02.07.2013)

R: Rodriguez-Ezpeleta N., Hackenberg M., Aransay A. M. (Eds.), Bioinformatics for High Throughput Sequencing, Springer 2012, ISBN 978-1-4614-0781-2

R: Cristianini N., Hahn W., Introduction to Computational Genomics. A case studies approach, Cambridge University Press 2012, ISBN: 978-0-521-67191-0

A: Brown S. M. (Ed.), Next-Generation DNA Sequencing Informatics, Cold Spring Harbor Laboratory Press 2012, ISBN: 978-1-936113-87-3

A: Hahne F., Huber W., Gentleman R., Falcon S., Bioconductor Case Studies, Springer 2008, ISBN: 978-0-387-77240-0

Learning resources -
Last update: ROZ143 (09.08.2013)


Syllabus -
Last update: ROZ143 (09.08.2013)

1. Introduction

2. Bacterial genome assembly - Achromobacter

3. Eukaryotic genome project I - Mastigamoeba, assembly from z 454, Illumina and PacBio sequences

4. Eukaryotic genome project II - repeats and other problematic stretches, assembly evaluation

5. Eukaryotic genome project III - gene prediction, annotation

6. RNA-Seq of the known genome, analysis of gene expression

7. Exploratory RNA-Seq of unknown genomes - Cobitis

8. Analysis of gene expression of tumorous tissues using microarrays

9. Metagenomics, analysis of poluted ground water

10. Phylogenetic analysis of the SARS epidemic

11. Comparative genomics, Burkholderia

12. Epigenetic analysis, melanomes


14. Genotyping analysis, porphyria

Registration requirements -
Last update: ROZ143 (09.08.2013)

Biochemistry, Molecular genetics, Bioinformatics

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Příprava na zkoušku a její absolvování 1 28
3 / 3 84 / 84
Coursework assessment
Form Significance
Oral examination 100