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The course covers selected technological procedures from the point of view of a selection from alternative methods and possibilities how to affect efficiency and capacity of these operations. It emphasizes user view of unit technological operations.
Last update: TAJ342 (18.12.2013)
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Students will be able to: Design a suitable isolation or separation method to obtain a pure organic compound from a mixture Optimize efficiency and capacity of isolation or separation method Select a suitable separation method Have an overview of technological aspects of discussed isolation and separation methods Understand physical-chemical principles of isolation and separation of organic compounds Last update: MORAVCOJ (01.02.2018)
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R: Fogler H.S.: Elements of Reaction Engineering,Prentice,Hall,New Jersey,2000,0130473944 Last update: TAJ342 (30.09.2013)
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Lecture notes Last update: TAJ342 (30.09.2013)
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1. Introduction, formulation of a problem, process characterization, up and down stream processes, economical aspects, operation safety 2. Features of organic and bioorganic compounds suitable for separation, their modification, nonbonding interactions, pH, ion-pairs, micells 3. Separation of solid particles: filtration, membrane processes, centrifugation, treatment of suspension 4. Isolation methody: Extraction, batch extraction, continuous extraction, Craig extraction, effect of pH, ion pairs formation, mass balance, artition equilibrium 5. Isolation method: Adsorption, batch, continuous, adsorption on a fixed bed, mass balance, adsorption equilibrium 6. Isolation methods: adsorption on a fixed bed, breakthrough diagrams, approximative analysis, two-parameters model 7. Sorbents, characteristics, application, liquid phase selection 8. Chromatography: thermodynamic and kinetic theory, analytical and preparative mode, instrumentation 9. Chromatography: eluation LC, Gauss equation, Poisson distribution, variance and standard deviation 10. Calculation of yield and purity of target compound in collected fractions 11. Chromatography: up-scaling 12. Electromigration methods, analytical and preparative 13. Gas chromatography: stationary phases, instrumentation, derivatization 14. Final polishing: destilation, crystallization, drying, precipitation Last update: MORAVCOJ (01.02.2018)
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Organic chemistry Mathematics I General and inorganic chemistry Last update: TAJ342 (30.09.2013)
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Absolvování zápočtového testu Ústní zkouška Last update: MORAVCOJ (21.11.2012)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.3 | 7 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.5 | 14 | ||
Příprava na zkoušku a její absolvování | 1.7 | 47 | ||
Účast na seminářích | 0.5 | 14 | ||
4 / 4 | 110 / 112 |
Coursework assessment | |
Form | Significance |
Regular attendance | 20 |
Continuous assessment of study performance and course -credit tests | 30 |
Oral examination | 50 |