SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Chemistry of Natural Compounds: Selected Chapters - N342011
Title: Vybrané kapitoly z chemie přírodních látek
Guaranteed by: Department of Chemistry of Natural Compounds (342)
Actual: from 2018
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1 C+Ex [hours/week]
Capacity: 20 / 20 (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Drašar Pavel prof. RNDr. DSc.
Jurášek Michal Ing. Ph.D.
Annotation -
Last update: TAJ342 (18.12.2013)
The course is an introduction to the study of natural compounds with their most important representatives. For each group it introduces its nomenclature and occurence in natural material and in detail discusses synthetic steps leading to their preparation. It also discusses practical industry applications of individual groups of natural compounds.
Aim of the course -
Last update: TAJ342 (30.09.2013)

Students will be able to:

Classify natural compounds into individual groups of natural compounds

Name natural compounds according to nomenclature

Identify sources of natural compounds suitable for laboratory or industrial application

Design synthetic routes for required groups of natural compounds

Give basic overview of individual groups applications

Literature -
Last update: TAJ342 (30.09.2013)

R: McMurry J., Organic Chemistry, Brooks Cole, Pacific Grove 2000.

R: Boons G.J. (red.), Carbohydrate Chemistry, Blackie 1998.

R: Steglich W., et al. (red.), Natural Products, Thieme 2000.

R: Greene T., Wuts P.G.M.: Protective Groups in Organic Synthesis, 3rd ed., Wiley NY, 1999.

A: Budavari S. (red.), The Merck Index 12th ed., Merck Whitehouse Station, 1996.

A: Kocienski P.J.: Protecting Groups, Corrected Edition, Thieme Stuttgart, 2000.

A: McOmie J.F.W.: Protective Groups in Organic Chemistry, Plenum Press London, 1973.

A: Ferrier R.J., Collins P.M.: Monosaccharide chemistry, Penguin Books, Middlesex 1972.

A: Lewis D. E.: Organic Chemistry, A modern Perspective, WCB, Wm. C. Brown Publishers, London 1996.

A: Clayden J., Greeves N., Warren S., Wothers P.: Organic Chemistry, University Press, Oxford, 2001.

A: Nomenclature of Carbohydrates, Carbohydr. Res. 297, 1-97 (1997).

A: Blackburn G.M., Gait M.J. (Eds), Nucleic Acids in Chemistry and Biology, 2nd ed., OUP, Oxford, 1997.

A: Berg J, Tymoczko JL, Stryer L, Biochemistry, Freeman, NY, 2002.

Learning resources -
Last update: TAJ342 (30.09.2013)

http://www.vscht.cz/lam/new/vkzchpl.htm

Syllabus -
Last update: TAJ342 (30.09.2013)

1. Natural compounds as a source of inspiration for organic and food chemist, ecologist, and pharmaceutist

2. Occurrence and role of saccharides in nature

3. Nomenclature of saccharides, oligosaccharides and polysaccharides

4. Protecting groups strategy, principal of orthogonality

5. Synthesis of amino, thio, fluor and deoxy derivatives of saccharides and their biological activity and role in nature

6. Steroids, their nomenclature, natural occurrence, and possibilities of synthetic application

7. Terpenes and oligopeptides in nature and regulation of biological processes. Synthetic application, synthesis of peptide libraries

8. Natural glycosides and small conjugates with steroid, terpenic, and flavonoid aglycone, occurrence, role, and synthetic routes to their synthesis

9. Polysaccharides of plant or animal origin

10. Glyco proteins, glycol lipids, glycose amino glycans

11. Sugars as components of nucleic acids, their synthetic application. Nomenclature of nucleosides and nucleotides

12. Natural compounds as building blocks of supra molecules and nanodevices

13. Application of selected natural compounds and their derivatives in pharmacology

14. Abuse of selected natural compounds and their derivatives as recreational or addictive substances. Precursors

Registration requirements -
Last update: TAJ342 (30.09.2013)

None

Teaching methods
Activity Credits Hours
Účast na přednáškách 2 56
Práce na individuálním projektu 1 28
Příprava na zkoušku a její absolvování 1 28
4 / 4 112 / 112
Coursework assessment
Form Significance
Regular attendance 20
Oral examination 80

 
VŠCHT Praha