SubjectsSubjects(version: 853)
Course, academic year 2019/2020
  
Methods of Pharmaceuticals Analysis - N402055
Title: Metody analýzy léčiv
Guaranteed by: Department of Analytical Chemistry (402)
Actual: from 2019
Semester: winter
Points: winter s.:5
E-Credits: winter s.:5
Examination process: winter s.:
Hours per week, examination: winter s.:3/0 Ex [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
Is provided by: M402046
For type:  
Guarantor: Sýkora David doc. Dr. RNDr.
Is interchangeable with: M402046
Annotation -
Last update: Sýkora David doc. Dr. RNDr. (26.09.2016)
Principles and applications of frequently used analytical methods in pharmaceutical laboratories are discussed with focus on separation techniques and other relevant methods.
Aim of the course -
Last update: Sýkora David doc. Dr. RNDr. (26.09.2016)

Students will obtain knowledge on many important analytical techniques applied in pharma laboratories. The most frequently used techniques will be covered in detail.

Literature -
Last update: VED402 (01.10.2013)

R: High Performance Capillary Electrophoresis - firemní příručka, D.N. Heiger, Hewlett-Packard, 1992.

R: Basic Gas Chromatography - kniha, H.M. McNair and J.M. Miller, Wiley, 2009, ISBN: 978-0-470-43954-8.

R: Practical High-Performance Liquid Chromatography - kniha, V.R. Meyer, Wiley, 2010, ISBN:978-0-470-68218-0.

R: Introduction to Mass Spectrometry - kniha, J.T. Watson and O.D. Sparkman, Wiley, 2007, ISBN: 978-0-470-51634-8.

Learning resources -
Last update: Sýkora David doc. Dr. RNDr. (16.08.2013)

http://onlinelibrary.wiley.com/book/10.1002/9780470688427

Syllabus -
Last update: Sýkora David doc. Dr. RNDr. (26.09.2016)

1. Introduction to the separation methods, their basic characterization.

2. Capillary electrophoresis and electrochromatography.

3. Gas Chromatography (GC). Principles, injection techniques, columns, detectors.

4. Liquid chromatography (LC). Principles, separation modes, instrumentation, sorbents and columns, detectors.

5. Supercritical fluid chromatography. Principles and instrumentation.

6. Simulated Moving Bed technique. Description of the method, applications.

7. Solid phase extraction. Principles and applications.

8. Mass spectrometry (MS). Ionization techniques, analyzers, detectors, GC-MS a LC-MS.

9. Methods of drug analysis in solid phase.

10. Polymorphism of API and analytical methods used for their detection.

11. Dissolution and adsorption of drugs.

12. Spectroscopic techniques of drug analysis - 1.

13. Spectroscopic techniques of drug analysis - 2.

14. Registration of new pharmaceuticals.

Entry requirements -
Last update: Sýkora David doc. Dr. RNDr. (12.02.2018)

The students need to know analytical chemistry on the level of Analytical chemistry I.

Registration requirements -
Last update: Sýkora David doc. Dr. RNDr. (12.02.2018)

The students need to know analytical chemistry on the level of Analytical chemistry I.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,5 14
Účast na přednáškách 1,5 42
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0,5 14
Příprava na zkoušku a její absolvování 2,5 70
5 / 5 140 / 140
Coursework assessment
Form Significance
Regular attendance 20
Examination test 80

 
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