SubjectsSubjects(version: 853)
Course, academic year 2019/2020
  
Introduction to Structure Analysis of Pharmaceutical Compounds - N402060
Title: Úvod do strukturní analýzy farmaceutických látek
Guaranteed by: Department of Analytical Chemistry (402)
Actual: from 2013
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: 40 / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Guarantor: Dolenský Bohumil doc. Ing. Ph.D.
Matějka Pavel prof. Dr. RNDr.
Annotation -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)
The course introduces basic overview of methods used for structural analysis of pharmaceutical substances. It is focused on both spectral and diffractometric methods. The attention is dedicated to principles of methods, instrumentation, and especially interpretation of experimental data considering practical pharmaceutical applications.
Aim of the course -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

Students will be able to:

Explain principles of spectrometric and diffractometric methods used for structural analysis.

Describe experimental techniques which are appropriate for structural analysis for various types of pharmaceutical formulations.

Interpret experimental data for simple organic compounds with possible applications in pharmacy.

Literature -
Last update: VED402 (01.10.2013)

R:Moderní přístupy k farmaceutické analýze 2; Strukturní analýza léčiv, Dohnal J. a kol., Brno: Veterinární a farmaceutická univerzita Brno, 2009, ISBN: 978-80-7305-058-0.

A:NMR Spectroscopy in Pharmaceutical Analysis, Edited by: Holzgrabe, Ulrike; Wawer, Iwona; Diehl, Bernd; 2008 Elsevier, ISBN: 978-0-444-53173-5, Electronic ISBN: 978-0-0805-5819-6

A:Structure Determination of Organic Compounds - Tables of Spectral Data (3rd Edition), By: Pretsch, E., Bühlmann, P., Affolter, C.; 2000 Springer - Verlag, ISBN: 978-3-540-67815-1, Electronic ISBN: 978-1-60119-351-3

A:Crystal Structure Determination, By Massa, Werner, 2nd ed., 2004, Springer, ISBN: 978-3-540-20644-6

A:Structure Determination from Powder Diffraction Data (International Union of Crystallography Monographs on Crystallography) By W.I.F. David, K. Shankland, L.B. McCusker, and C. Bärlocher, OUP Oxford; New Ed edition Aug 2006, ISBN: 978-0199205530

Learning resources -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

electronic materials - lecture slides - available in the domain vscht.cz

Syllabus -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

1. Classes of methods of structural analysis

2. X-ray diffractometry - principles of the method

3. X-ray diffractometry - instrumentation

4. Analysis and evaluation of diffractograms

5. X-ray diffractometry - application in pharmaceutical analysis

6. NMR spectrometry - principles of the method

7. NMR spectrometry - analysis of solutions

8. NMR spectrometry - analysis of solids

9. Vibrational spectrometry - principles

10.Infrared spectrometry and structure of substances

11.Raman spectrometry and structure of substances

12.Infrared and Raman microspectrometry - mapping and imaging

13.Mass spectrometry and structure of chemical substances

14.Combination of methods of structural analysis - complex interpretation

Registration requirements -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

Introduction to spectral methods of drug analysis

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,5 14
Účast na přednáškách 1 28
Příprava na zkoušku a její absolvování 1,5 42
3 / 3 84 / 84
Coursework assessment
Form Significance
Regular attendance 10
Examination test 60
Oral examination 30

 
VŠCHT Praha