SubjectsSubjects(version: 902)
Course, academic year 2022/2023
  
Pharmaceutical Dosage Forms - P111007
Title: Lékové formy
Guaranteed by: Department of Organic Technology (111)
Actual: from 2022
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0 [hours/week]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Zbytovská Jarmila doc. Mgr. Dr. rer. nat.
Interchangeability : D111024
Is interchangeable with: AP111007
Examination dates   Schedule   
Annotation -
Last update: Zbytovská Jarmila doc. Mgr. Dr. rer. nat. (19.05.2022)
The subject is focused on technologies of drug formulation. Particular dosage forms are presented from two different points of views: the physico-chemical one and the organism-drug interactions one. Among others, issues concerning selection of appropriate excipients, drug formulation, quality and stability of dosage forms are discussed. Novel dosage forms of higher generations are presented as well.
Aim of the course -
Last update: Pátková Vlasta (30.05.2018)

Students will be able to:

  • apply physical-chemical backgrounds in drug formulation
  • evaluate the pros and cons of the particular dosage forms in concrete cases, including manufacturing
  • understand issues of selection of appropriate excipients; know their classification and utilization
  • independently solve model case studies on drug formulation and stability
Literature -
Last update: Zbytovská Jarmila doc. Mgr. Dr. rer. nat. (19.05.2022)

(R) European Pharmacopoeia

(R) Aulton M.: Pharmaceutics: The Design and Manufacture of Medicines. Elsevier Health Sciences 2021. ISBN 9780702081545.

(R) Allen L V., McPherson TB: Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems, 2021. Walters Kluwer, ISBN 9781975171773.

(A) Voigt R., Fahr A.: Pharmazeutische Technologie. Deutscher Apotheker Verlag, 2021. ISBN 978-3-7692-7306-9.

(A) Müller-Goymann: Bauer, Fröming, Führer / Lehrbuch der Pharmazeutischen Technologie. Wissenschaftliche Verlagsgesellschaft Stuttgart, 2022. ISBN 9783804738478.

(A) Mäder K., Weidenauer U.: Innovative Arzneiformen. Wissenschaftliche Verlagsgesellschaft Stuttgart, 2009. ISBN 978-3-8047-2455-6.

(A) Germershaus O: Martin Physikalische Pharmazie. Wissenschaftliche Verlagsgesellschaft Stuttgart, 2022. ISBN 9783804733299.

Časopisy:

(A) Advanced Drug Delivery Reviews

(A) Pharmaceutical Research

(A) International Journal of Pharmaceutics

(A) European Journal of Pharmaceutics and Biopharmaceutics

+ further literature according to the particular needs of the student

Teaching methods -
Last update: Zbytovská Jarmila doc. Mgr. Dr. rer. nat. (23.10.2018)

lectures, individual project preparation

Syllabus -
Last update: Zbytovská Jarmila doc. Mgr. Dr. rer. nat. (19.05.2022)

1. General definitions, classification of drug forms, pharmacopoeia and other standards

2. Physico-chemical backgrounds of drug formulation; Preformulation of drugs

3. Pharmaceutical excipients

4. Oral administration: fluid (solutions, suspensions emulsions) and solid (powders, granules, capsules, tablets) dosage forms

5. Parenteral administration: injections, infusions, implants and others

6. Topical administration: into the respiratory tract / ocular and auricular / rectal and vaginal dosage forms / dermal and transdermal dosage forms: fluid (solutions, suspensions, emulsions), semisolid (ointments, creams, gels) and solid (suppositories)

7. Modern dosage forms (with modified drug liberation; with drug targeting)

8. Solutions for troublesome drugs (with poor solubility and/or low bioavailability)

9. New aspects of dosage forms development (nanoparticulate systems, innovative excipients)

10. Pharmaceutical packaging

11. Stability of pharmaceutical preparations

Course completion requirements -
Last update: Zbytovská Jarmila doc. Mgr. Dr. rer. nat. (23.10.2018)

Project presentation and final exam.

 
VŠCHT Praha