SubjectsSubjects(version: 850)
Course, academic year 2019/2020
  
Molecular Mechanisms of Bacteria-Host Interactions - P320002
Title in English: Molekulární podstata interakcí bakterií s hostiteli
Guaranteed by: Department of Biochemistry and Microbiology (320)
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0 other [hours/week]
Capacity: winter:unlimited / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
you can enroll for the course in winter and in summer semester
Guarantor: Šebo Peter prof. Ing. CSc.
Interchangeability : D320065
Is interchangeable with: AP320002
Annotation -
Last update: Kubová Petra Ing. (11.04.2018)
The subject deals with cellular and molecular biology of host-pathogen interactions, placing a particular emphasis on mechanisms by which bacteria manipulate the immunity of the host. Specific attention is paid to regulation of gene expression and to genes involved in virulence of bacterial pathogens. The mechanisms of evasion from host immunity and action of adhesins, toxins and other virulence factors are analyzed in detail using prototypic examples of human and animal pathogens.
Aim of the course -
Last update: Kubová Petra Ing. (11.04.2018)

The students will acquire profound knowledge in the fields of bacteriology, antiinfectious immunity, molecular mechanisms of bacterial virulence and cellular action of bacterial toxins. The potential practical use of acquired knowledge is in research, vaccine and diagnostics develeopment and clinical in microbiology laboratories

Literature -
Last update: Kubová Petra Ing. (11.04.2018)

Z: Brenda A. Wilson,‎ Abigail A. Salyers,‎ Dixie D. Whitt,‎ Malcolm E. Winkler: Bacterial Pathogenesis: A Molecular Approach, 3rd edition 2010 ASM Press, ISBN-13: 978-0632037759

Z:Kenneth Murphy, Casey Weaver: Janeway's Immunobiology, Ninth Edition (Immunobiology: The Immune System (Janeway), 2017, Garland Science, ISBN-13: 978-0815345053

D:Goering R., Dockrell H., Roitt I., et al.: Mims' Medical Microbiology, 2012, ELSEVIER, ISBN 9780808924401, 9780702056635.

Learning resources
Last update: Kubová Petra Ing. (11.04.2018)

https://l125lsx.mbu.cas.cz/BacPatho/

Syllabus -
Last update: Kubová Petra Ing. (11.04.2018)

1. Co-evolution of bacterial pathogens with their hosts – basic concepts of interaction

2. The immune system of mammals and mucosal and systemic immunity to infection

3. Genomes of bacterial pathogens, horizontal gene transfer and regulation of gene expression

4. The microbial organ – microbiomes of the host in health and disease

5. Basic categories of virulence factors and pathways of their secretion beyond the bacterial membrane

6. Types and mechanisms of action of bacterial protein toxins

7. Pathways and mechanisms of intracellular penetration and survival of bacterial pathogens

8. Experimental system for host-pathogen interaction studies and identification of involved genes

9. basic vaccine types, their design and development

10. Mechanisms of virulence of the genera Bordetella, Mycobacterium, Neisseria, Listeria

11. Corynebacterium diphteriae, Streptococcus pyogenes a Staphylococcus aureus.

12. Clostridium botulinum, perfrigens, tetani, B. cereus, Helicobacter pylori.

13. Ricketsia, Francisella, Coxiella, Neisseria, Listeria, Borrelia, Mycoplasma, Chlamydia

14. Yersinia, Salmonella, Shigella, Vibrio cholerae. Escherichia coli, EPEC, ETEC, UPEC, NMEC.

Registration requirements - Czech
Last update: Kubová Petra Ing. (11.04.2018)

nejsou

Course completion requirements -
Last update: Šebo Peter prof. Ing. CSc. (20.06.2018)

The course is terminated by an exam consisting of a written test, presentation and examination.

Coursework assessment
Form Significance
Oral examination 100

 
VŠCHT Praha