SubjectsSubjects(version: 877)
Course, academic year 2020/2021
  
Circular Dichroism Spectroscopy - P444001
Title: Spektroskopie cirkulárního dichroismu
Guaranteed by: Department of Physics and Measurement (444)
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0 other [hours/week]
Capacity: winter:unlimited / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Urbanová Marie prof. RNDr. CSc.
Interchangeability : D444002
Z//Is interchangeable with: AP444001
Annotation -
Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)
The course represents the concepts of chiroptical methods as specific spectroscopic methods for the structural study of chiral molecular and supramolecular systems. It covers the theoretical basics and the concepts of chiroptical instrumental methods and the methodology of chiroptical measurements. The variants of chiroptical methods are described. Their advantages, disadvantages and limits are discussed. The special focus is devoted to spectroscopy of electronic and vibrational circular dichroism and their application in the study of biologically important interactions and chiral recognition.
Aim of the course -
Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)

Students obtain:

• theoretical basics and the concepts of chiroptical instrumental methods

• knowledge of the application of chiroptical methods for structural study of molecular and supramolecular systems

• knowledge how to deal with experimental outputs in chiroptical spectroscopies

• knowledge of application of chiroptical spectroscopies in biologically important interactions

• participation in the demo measurements of electronic and vibrational dichroic spectra

Literature -
Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)

1.Urbanová M., Maloň P. Circular Dichroism Spectroscopy v Analytical Methods in Supramolecular Chemistry (Schalley C. A., Ed.), 2nd edition, Wiley VCH: Weinheim, Germany, 2012, p. 337-369, ISBN: 978-3-527-32982-3. http://onlinelibrary.wiley.com/book/10.1002/9783527610273

2. Setnička V., Urbanová M. Spektroskopie cirkulárního dichroismu v Moderní přístupy k farmaceutické analýze (Dohnal J., Jampílek J., Král V., Řezáčová A., Eds.), Farmaceutická fakulta Veterinární a farmaceutické univerzity Brno: Brno, 2010, kapitola 4.6.

Learning resources -
Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)

Analýza chirálních sloučenin (Tesařová E., Ed.), Pražské analytické centrum inovací: Praha, 2007, ISBN: 978-80-86238-23-4.

Teaching methods -
Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)

lectures

Demo measurements of electronic and vibrational circular dichroism

Syllabus -
Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)

1. Polarization of radiation utilized in chiroptical methods

2. Molecular and supramolecular chirality

3. Theoretical basics of chiroptical methods

4. Observable quantities and units used in chiroptical spectroscopy (circular dichroism, ellipticity, optical rotatory dispersion, dissymmetry factor)

5. Interaction of circularly polarized radiation with matter, rotational strength of transition, relation between observables and structure of chiral molecules

6. Methodology of circular dichroism measurements and dedicated devices

7. Electronic circular dichroism, instrumentation, how to obtain reliable spectra

8. Vibrational circular dichroism, its particularity, instrumentation, how to obtain reliable spectra and structural data

9. Variants of chiroptical methods: optical rotation and optical rotatory dispersion, fluorescence detected circular dichroism and their instrumentation

10. Variants of chiroptical methods: circularly polarized luminescence, magnetic optical activity and their instrumentation

11. Raman optical activity and its instrumentation

12. Ab initio calculations of chiroptical properties and their relation to experiment

13. Application of circular dichroism generally and in study of biologically important interactions and of chiral supramolecular systems

14. Demo experiments in electronic circular laboratory and in vibrational circular dichroism laboratory

Course completion requirements -
Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)

Oral examination

 
VŠCHT Praha