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Last update: Kubová Petra Ing. (06.05.2019)
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Last update: Kubová Petra Ing. (06.05.2019)
Students will know: Basic principles of molecular genetics and the relationship of their structure and function. Principles of regulation of transfer of genetic information and its variability due to mutations and recombination Mechanisms involved in mutation repair. Basic processes of gene expression as regulation of transcription, in prokaryotes and eukaryotes and posttranscriptional modifications of eukaryotic mRNA, regulation of stability of mRNA and translation, role of small RNAs. Basic principles of DNA analysis and basic applications of polymerase chain reaction Basic principles of pharmacogenomics and oncogenesis |
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Last update: Kubová Petra Ing. (06.05.2019)
R: Lodish, H.; et al. Molecular cell biology, 8th ed.;W.H.Freeman & Co Ltd, 2016.
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Last update: Kubová Petra Ing. (06.05.2019)
Berk A., Lodish H., Kaiser Ch. A.: (2016) Molecular Cell Biology, 8th Edition, Palgrave Macmillan |
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Last update: Kubová Petra Ing. (06.05.2019)
1. Historic overview and basic genetic laws and terms. 2. Structure and function of nucleic acids, genome organization 3. Replication, DNA polymerases, replisome complex. 4. Mutations and repair mechanisms. 5. Recombination, gene segregation. 6. Transposition, transduction, regulation of yeast mating type. 7. Regulation of prokaryotic transcription. 8. Eukaryotic transcription, posttranscriptional modifications of RNA. 9. Regulatory roles of RNA. 10. Translation. 11. Comparison of prokaryotic and eukaryotic translation, post-translational modification. 12. DNA analysis for identification of persons. 13. Fundamentals of pharmacogenomics. 14. Genetic principles of cancer. |
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Last update: Kubová Petra Ing. (06.05.2019)
To enroll in the course it is required enrollment in courses N110004 A N320004 |
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Last update: Kubová Petra Ing. (06.05.2019)
Biochemistry I |
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Last update: Kubová Petra Ing. (06.05.2019)
completed written and oral exams |