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The course covers basic groups of natural compounds, their properties and utilization. It explains also basic concepts related to structure of molecules, their stereochemistry and chirality including structure-biological activity relationships.
Last update: Kubová Petra (06.05.2019)
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Students will be able to: Name compounds according to nomenclature of organic compounds Describe structure, properties and reactions of individual groups of organic compounds as well as their biogenesis Assess configuration, chirality and likely conformations based on the structural formula Depict reaction mechanisms of basic reaction types Last update: Kubová Petra (06.05.2019)
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Podmínkou pro udělení zápočtu jsou dva průběžné testy s výsledkem nad 50 %. Předmět je ukončen ústní zkouškou. Last update: Kubová Petra (06.05.2019)
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1. Bioorganic chemistry, definition of natural compounds, overview, occurrence, and nomenclature 2. Stereochemistry of natural compounds, chirality 3. Isolation of a compound, structure determination 4. Relationships between structure, biogenesis and biological activity 5. Monosaccharides, nucleophillic addition on carbonyl group 6. Oligosaccharides, polysaccharides 7. Amines, basicity, nucleophilicity 8. Alkaloids, nucleosides, narcotics, drugs 9. Hydroxy acids, acidity 10. Amino acids, peptides, proteins 11. Lipids, prostaglandins 12. Terpenoids, electrophilic addition, polyphenols 13. Antibiotics, narcotics, drugs, patent policy 14. Metabolic pathways assessment, precursor labeling, metabolites tracing, falsification of foodstuffs
Last update: Kubová Petra (06.05.2019)
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Lecture notes Last update: Kubová Petra (06.05.2019)
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Organic chemistry I Last update: Kubová Petra (06.05.2019)
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