SubjectsSubjects(version: 875)
Course, academic year 2019/2020
Retrosynthesis - AM110004
Title: Retrosynthesis
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: summer
Points: summer s.:6
E-Credits: summer s.:6
Examination process: summer s.:
Hours per week, examination: summer s.:3/1 C+Ex [hours/week]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Cibulka Radek prof. Ing. Ph.D.
Incompatibility : M110004
Interchangeability : M110004, S110013
N//Is incompatible with: M110004
Z//Is interchangeable with: M110004
Last update: Kundrát Ondřej Ing. Ph.D. (24.01.2018)
The aim of this course is introduction of the disconnection approach to organic synthesis. This approach is analytical: we start with the molecule we want to make (the target molecule) and break it down by a series of disconnections into possible starting materials. During the course, the retrosynthetic method is shown on simple as well as on more complicated structures which are known from practical life: pharmaceuticals, pesticides, dyes, perfumes etc.
Last update: Kundrát Ondřej Ing. Ph.D. (24.01.2018)

R: Warren S., Wyatt P.: Organic synthesis - The disconnection approach, 2nd Edition, John Wiley, 2008, 9780470712368

A: Warren S., Wyatt P.: Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition, John Wiley, 2009, 9780470712276

A: Wyatt P., Warren S.: Organic Synthesis - Strategy and Control, John Wiley, 2007, 9780470489405

Syllabus -
Last update: Kundrát Ondřej Ing. Ph.D. (15.02.2018)

1. The disconnection approach. Basic principles.

2. Oxidation states of organic compounds.

3. One group C-X disconnections.

4. Two group C-X disconnections.

5. One group C-C disconnections: alcohols.

6. One group C-C disconnections: carbonyl compounds.

7. Alkene and alkyne synthesis.

8. Two group disconnections. 1,3- and 1,5-difunctionalised compounds.

9. Two group disconnections. 1,2-, 1,4- and 1,6-difunctionalised compounds.

10. Strategy of ring synthesis. Baldwin's rules. 3-, 4- and 5-membered rings.

11. Six-membered rings.

12. Heterocycles.

13. Stereoselective synthesis.

14. Linear and convergent synthesis.

Registration requirements
Last update: Kundrát Ondřej Ing. Ph.D. (24.01.2018)

Organic Synthesis

Course completion requirements -
Last update: Kundrát Ondřej Ing. Ph.D. (15.02.2018)

It is compulsory to prepare project on the synthesis of natural compound, to pass written examination test with the result at least 60%, and finally to pass successfuly the oral examination.

Teaching methods
Activity Credits Hours
Účast na přednáškách 1,5 42
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1,5 42
Práce na individuálním projektu 0,5 14
Příprava na zkoušku a její absolvování 2 56
Účast na seminářích 0,5 14
6 / 6 168 / 168
Coursework assessment
Form Significance
Examination test 50
Oral examination 50