SubjectsSubjects(version: 899)
Course, academic year 2021/2022
Bioengineering I - AM319004
Title: Bioengineering I
Guaranteed by: Department of Biotechnology (319)
Actual: from 2021
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1 C+Ex [hours/week]
Capacity: 15 / 15 (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Halecký Martin doc. Ing. Ph.D.
Páca Jan prof. Ing. DrSc.
Interchangeability : M319004, N319008
Is interchangeable with: M319004
This subject contains the following additional online materials
Annotation -
Last update: Kubová Petra Ing. (25.04.2018)
The course focuses on understanding and quantitative description of biological processes in the context of their implementation under defined conditions enabling to achieve reproducibility of results. The syllabus is based on the principles of kinetics, balancing as well as measurement and regulation of biological processes, including the design of the equipment.
Aim of the course -
Last update: Kubová Petra Ing. (25.04.2018)

Students will be able to:

Understand the biological, chemical and engineering processes in the biotechnology industry

Describe and evaluate basic biocatalytic processes.

Quantitatively evaluate experimental data of processes catalyzed by biological elements and to carry out heat and mass balances of biotechnological processes.

Design mixing and aeration equipment of bioreactors.

Literature -
Last update: Kubová Petra Ing. (25.04.2018)

R: Doran P.M.: Bioprocess Engineering Principles, Academic, London, 1995, ISBN: 9780122208553

R: Moo-Young M.: Comprehensive biotechnology, Elsevier B.V., 2011, ISBN: 9780080885049

A: Dunn I.J. et al.: Biological Reaction Engineering, Wiley-VCH, 2003, ISBN:9783527307593

A: Najafpour G.D.: Biochemical Engineering and Biotechnology, Elsevier B.V., 2007, ISBN 9780444528452

Learning resources -
Last update: Kubová Petra Ing. (25.04.2018)

Syllabus -
Last update: Brányik Tomáš prof. Ing. Ph.D. (10.05.2018)

1. Engineering aspects of biotechnology

2. The structure of bioprocess, equipment overview and unit operations

3. Methods of optimization and modeling of biological processes

4. Engineering kinetics of chemical and enzymatic reactions

5. Cultivation of microorganisms - kinetics of microbial growth, batch cultures

6. Cultivation of microorganisms - fed-batch, semicontinuous and continuous cultures

7. Characteristics of phase flow - residence time distribution, flow models

8. Mass transfer - oxygen transfer, aeration, measurement and quantification of kLa

9. Specific aspects of plant/tissue cell and phototrophic cell cultivation

10. Specific aspects of plant and tissue cell cultivation

11. Mixing in bioreactors - theory, power consumption, homogenization, shear force

12. Heat transfer, energy balance of bioreactors, sterilization, cooling and heating

13. Scale-up of bioprocesses

14. Construction materials and corrosion

Course completion requirements -
Last update: Kubová Petra Ing. (25.04.2018)

Credit test (rated at least 50%).

Exam test (rated at least 50%).

Oral exam.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,2 6
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0,5 14
Příprava na zkoušku a její absolvování 1,8 50
Účast na seminářích 0,5 14
4 / 4 112 / 112