SubjectsSubjects(version: 955)
Course, academic year 2023/2024
Bioorganic chemistry of saccharides and nucleic acids - AP342004
Title: Bioorganic chemistry of saccharides and nucleic acids
Guaranteed by: Department of Chemistry of Natural Compounds (342)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0, other [HT]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Parkan Kamil doc. Ing. Ph.D.
Šimák Ondřej Ing. Ph.D.
Rejman Dominik doc. Ing. CSc.
Interchangeability : P342004
Annotation -
Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into molecular level of the processes in biological systems. The course of Bioorganic chemistry of saccharides and nucleic acids covers the area at the interface between organic chemistry and biochemistry or biology. It comprises chemical and enzymatic synthesis of simple and complex carbohydrates and nucleotides and modern analytical methods of their structure and reviews the ways in which carbohydrates mediate binding to cell and subcellular targets such as DNA, proteins, and antibody binding sites. It also provides the biosynthesis of carbohydrates and nucleotides. Importance of their analogs as molecular tools for biological studies and existing or potential drugs will be covered as well as their synthesis.
Last update: Pátková Vlasta (15.11.2018)
Aim of the course -

Students will be able to:

understand the structure and function of saccharides and nucleic acid

chemical and enzymatic synthesis of oligosaccharides, oligonucleosides and their analogs

understand molecular principles and reaction mechanism of biological and biochemical processes

Last update: Pátková Vlasta (15.11.2018)
Literature -

Sidney M. Hecht: Bioorganic Chemistry: Carbohydrates, Oxford University Press; 1999. ISBN: 9780195084696.

Sidney M. Hecht: Bioorganic Chemistry: Nucleic Acids, Oxford University Press; 1996. ISBN: 9780195084672.

Hans-Joachim Gabius: The Sugar Code. Fundamentals of Glycosciences, Wiley -VCH Verlag, Weinheim 2009. ISBN: 9783527320899.

B. Ernst, G. W. Hart, P. Sinay: Carbohydrates in Chemistry and Biology, 2000 Wiley -VCH Verlag, Weinheim. ISBN: 9783527295111.

Last update: Pátková Vlasta (15.11.2018)
Learning resources -

Copies of all presentation available from the lecturer.

Last update: Pátková Vlasta (15.11.2018)
Teaching methods - Czech

Přednášky vyučujících, prezentace studentů na jimi zvolené a zpracované téma zahrnující samostudium.

Last update: Pátková Vlasta (15.11.2018)
Syllabus -

The first part will be focused to understanding basic physical, chemical, and biological properties of saccharides and nucleic acids. a) stereochemistry, biological functions, b) chemical and enzymatic synthesis of glycosides and nucleic acid components.

The second part will be devoted to understanding biochemical processes a) models of cellular saccharide epitops, b) recognition of saccharide antigens by antibodies, c) interaction between proteins and saccharides.

The third part will deal with a) drug design, b) synthesis of analogs of saccharides and nucleosides.

Last update: Pátková Vlasta (15.11.2018)
Course completion requirements -

Evaluation of presentation on current topic from the field of bioorganic chemistry of saccharides or nucleic acids. It is compulsory to pass written examination test with the result at least 60 %.

Last update: Pátková Vlasta (15.11.2018)