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Bioorganic Chemistry of Natural Compounds represents a modern interdisciplinary field at the interface of organic chemistry, biochemistry, and biology. The course focuses on the relationship between the structure and function of biomolecules from the perspective of organic chemistry. It explains the molecular principles of biological and biochemical processes, compares different classes of biomolecules, and covers both the chemical synthesis and biosynthesis of natural compounds and biomacromolecules.
Furthermore, it addresses the isolation and identification of various natural products using advanced analytical techniques. The course provides a deeper insight into the structure–function relationship of natural compounds, highlights the principles of their interactions with biological macromolecules, and emphasizes the importance of natural compounds and their analogues as tools for studying biological processes, as starting points for drug design, and as bioactive molecules with application potential.
Last update: Cibulková Jana (11.09.2025)
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Evaluation is based on a presentation on a current topic in the field of bioorganic chemistry of natural compounds. Passing the written examination with a minimum score of 60% is required. Last update: Cibulková Jana (11.09.2025)
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Sidney M. Hecht: Bioorganic Chemistry: Carbohydrates, Oxford University Press; 1999. ISBN: 9780195084696. Sidney M. Hecht: Bioorganic Chemistry: Nucleic Acids, Oxford University Press; 1996. ISBN: 9780195084672. Hans-Joachim Gabius: The Sugar Code. Fundamentals of Glycosciences, Wiley -VCH Verlag, Weinheim 2009. ISBN: 9783527320899. B. Ernst, G. W. Hart, P. Sinay: Carbohydrates in Chemistry and Biology, 2000 Wiley -VCH Verlag, Weinheim. ISBN: 9783527295111. Last update: Pátková Vlasta (15.11.2018)
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Přednášky vyučujících, prezentace studentů na jimi zvolené a zpracované téma zahrnující samostudium. Last update: Pátková Vlasta (15.11.2018)
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Block I: Fundamentals and Principles The introductory part of the course presents bioorganic chemistry of natural compounds as a modern discipline at the intersection of organic chemistry, biochemistry, and biology. Students will become familiar with the major classes of biomolecules, their structure and function, as well as with the chemical and enzymatic principles of their synthesis and biosynthesis. Block II: Isolation and Analysis The second part focuses on how natural compounds can be obtained from various sources and how they can be further purified and characterized. Students will learn the basic approaches to isolation and modern analytical methods that enable the determination of the structure and properties of natural compounds and their interactions with biological macromolecules. Block III: Applications and Contexts The final part demonstrates how knowledge from bioorganic chemistry is applied in practice. Topics include the use of enzymes in synthesis (biocatalysis), chemical biology and synthetic biology, as well as the importance of natural compounds and their derivatives as drugs and bioactive molecules. Current trends and future perspectives of the field are also discussed. Last update: Cibulková Jana (11.09.2025)
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Copies of all presentation available from the lecturer. Last update: Pátková Vlasta (15.11.2018)
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Students will be able to: understand the structure and function of saccharides and nucleic acid chemical and enzymatic synthesis of oligosaccharides, oligonucleosides and their analogs understand molecular principles and reaction mechanism of biological and biochemical processes Last update: Pátková Vlasta (15.11.2018)
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