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Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into molecular level of the processes in biological systems. The course of Bioorganic chemistry of saccharides and nucleic acids covers the area at the interface between organic chemistry and biochemistry or biology. It comprises chemical and enzymatic synthesis of simple and complex carbohydrates and nucleotides and modern analytical methods of their structure and reviews the ways in which carbohydrates mediate binding to cell and subcellular targets such as DNA, proteins, and antibody binding sites. It also provides the biosynthesis of carbohydrates and nucleotides. Importance of their analogs as molecular tools for biological studies and existing or potential drugs will be covered as well as their synthesis.
Last update: Pátková Vlasta (15.11.2018)
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Students will be able to: understand the structure and function of saccharides and nucleic acid chemical and enzymatic synthesis of oligosaccharides, oligonucleosides and their analogs understand molecular principles and reaction mechanism of biological and biochemical processes Last update: Pátková Vlasta (15.11.2018)
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Evaluation of presentation on current topic from the field of bioorganic chemistry of saccharides or nucleic acids. It is compulsory to pass written examination test with the result at least 60 %. Last update: Pátková Vlasta (15.11.2018)
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Sidney M. Hecht: Bioorganic Chemistry: Carbohydrates, Oxford University Press; 1999. ISBN: 9780195084696. Sidney M. Hecht: Bioorganic Chemistry: Nucleic Acids, Oxford University Press; 1996. ISBN: 9780195084672. Hans-Joachim Gabius: The Sugar Code. Fundamentals of Glycosciences, Wiley -VCH Verlag, Weinheim 2009. ISBN: 9783527320899. B. Ernst, G. W. Hart, P. Sinay: Carbohydrates in Chemistry and Biology, 2000 Wiley -VCH Verlag, Weinheim. ISBN: 9783527295111. Last update: Pátková Vlasta (15.11.2018)
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Přednášky vyučujících, prezentace studentů na jimi zvolené a zpracované téma zahrnující samostudium. Last update: Pátková Vlasta (15.11.2018)
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The first part will be focused to understanding basic physical, chemical, and biological properties of saccharides and nucleic acids. a) stereochemistry, biological functions, b) chemical and enzymatic synthesis of glycosides and nucleic acid components. The second part will be devoted to understanding biochemical processes a) models of cellular saccharide epitops, b) recognition of saccharide antigens by antibodies, c) interaction between proteins and saccharides. The third part will deal with a) drug design, b) synthesis of analogs of saccharides and nucleosides. Last update: Pátková Vlasta (15.11.2018)
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Copies of all presentation available from the lecturer. Last update: Pátková Vlasta (15.11.2018)
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