SubjectsSubjects(version: 944)
Course, academic year 2019/2020
Engineering in the Pharmaceutical Industry - B111012
Title: Inženýrství farmaceutických výrob
Guaranteed by: Department of Organic Technology (111)
Faculty: Faculty of Chemical Technology
Actual: from 2019 to 2019
Semester: winter
Points: winter s.:5
E-Credits: winter s.:5
Examination process: winter s.:
Hours per week, examination: winter s.:3/0, Ex [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
For type: Bachelor's
Additional information: http://předmět vyučován pouze v zimním semestru
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Zámostný Petr prof. Ing. Ph.D.
Patera Jan Ing. Ph.D.
Interchangeability : N111014
Is interchangeable with: AB111012
Examination dates   Schedule   
This subject contains the following additional online materials
Annotation -
Last update: Kubová Petra Ing. (03.01.2018)
The course provides knowledge of the preparation of dosage forms, which are crucial for the formulation of pharmaceutical products. Principles of liquid, semi-solid and solid dosage forms and methods for assessing their quality are explained, using chemical engineering principles and knowledge of physical chemistry and other disciplines. Particular attention is paid to particulate solids, their storage, transport, mixing, granulation and tabletting. Biotech synthesis of antibiotics in aerobic digesterare are discussed separately.
Aim of the course -
Last update: Kubová Petra Ing. (03.01.2018)

Students will be able to:

Apply theoretical knowledge to specific processes used in industry.

Apply theoretical knowledge on research of processes of pharmaceutical industry, including biotechnology synthesis of antibiotics.

Analyze and combine the basic operational processes of manufacture of dosage forms in the pharmaceutical industry.

Acquire basic analytical methods for the evaluation of solid dosage forms according to the Czech Pharmacopoeia.

Literature -
Last update: Kubová Petra Ing. (03.01.2018)

R:Perry R. H., Green D. W.,Chemical Engineer’s Handbook,McGraw Hill,New York,1997,0070498415.

R:Sajvera J.,Technologie farmaceutických výrob II,Informatorium,Praha,1993,8085427303.

A:Komárek P.,Rabišková M. a kolektiv,Technologie léků,Galén,Praha,2006,8072624237.

A:Levin M.: Pharmaceutical process scale up,Decker,New York,2002,0824706250.

A:Hanika J.,Speciální separační procesy,VŠCHT,Praha 1999,8070802421.

Learning resources -
Last update: Patera Jan Ing. Ph.D. (10.01.2018)

Requirements to the exam - Czech
Last update: Patera Jan Ing. Ph.D. (11.01.2018)

1. Písemná zkouška

2. Ústní zkouška

Syllabus -
Last update: Patera Jan Ing. Ph.D. (10.01.2018)

1. Dosage forms, classification.

2. Solid materials, characteristics, classification.

3. Crushing, milling, storage and transport of solids Handling of solids, mixing, size reduction.

4. Homogenization, technology, equipment.

5. Wet granulation, technology, equipment. Pressure compaction of solids.

6. Drugs formulation, solid dosage forms, methods of quality assessment.

7. Solid dosage forms, tablettes, capsules and their manufacturing.

8. Semi solid formulations.

9. Extraction, liquid dosage forms.

10. Basic principles of sterilization.

11. Theory of fermentation processes, growth law for micro-organism population.

12. Bioreactors for aerobic processes.

13. Fermentation control, micro-organism separation.

14. Separation processes, filtration, lyophilization.

Entry requirements - Czech
Last update: Patera Jan Ing. Ph.D. (08.09.2023)

Pro zápis tohoto předmětu je nutno mít minimálně zapsán předmět N409002

Registration requirements -
Last update: Kubová Petra Ing. (03.01.2018)

Unit Operations of Chemical Engineering I

Physical Chemistry I

Course completion requirements - Czech
Last update: Patera Jan Ing. Ph.D. (19.02.2018)

Studenti musí napsat zkouškový test na více než 50 % bodů a uspět u ústní zkoušky.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0.5 14
Účast na přednáškách 1.5 42
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Příprava na zkoušku a její absolvování 2 56
5 / 5 140 / 140
Coursework assessment
Form Significance
Regular attendance 5
Examination test 80
Oral examination 15