SubjectsSubjects(version: 955)
Course, academic year 2023/2024
Laboratory of Specialization Synthesis of Drugs - M110010
Title: Laboratoř specializace - syntéza léčiv
Guaranteed by: Department of Organic Chemistry (110)
Faculty: Faculty of Chemical Technology
Actual: from 2019
Semester: winter
Points: winter s.:7
E-Credits: winter s.:7
Examination process: winter s.:
Hours per week, examination: winter s.:0/10, MC [HT]
Capacity: unknown / unlimited (unknown)
Min. number of students: unlimited
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Note: enabled for web enrollment
Guarantor: Kvíčala Jaroslav prof. Ing. CSc.
Rybáčková Markéta Ing. Ph.D.
Class: Základní laboratoře
Interchangeability : N110032
Annotation -
The aim of the subject is to acquire both theoretical and experimental knowledge of modern laboratory techniques. Among the performed experiments are cross-coupling reactions, photochemical reactions and other reactions that require handling of organometallic and hydride reagents, working under inert atmosphere using inert lines and septum techniques, working in a glovebox, working with a microwave reactor, working at low temperatures and with low-boiling liquids. The products obtained will be isolated by advanced separation techniques (vacuum distillation, crystallization and column chromatography) and their structure and purity will be determined by selected analytical methods (NMR spectroscopy, TLC, UV/VIS spectroscopy).
Last update: Rybáčková Markéta (11.09.2023)
Aim of the course -

Students will be able to:

work under inert atmosphere using an inert line and septum techniques

work at low temperatures

work in a glovebox

work with a microwave reactor

work with an instrument for flash chromatography

work with low-boiling liquids

work with organometallic and hydride reagents

measure UV spectra and analyse a reaction mixture by HPLC

Last update: Rybáčková Markéta (11.09.2023)
Literature -

The literature is determined individually for each student by his or her supervisor.

Last update: Rybáčková Markéta (01.11.2019)
Learning resources -

Printed experimental procedures.

Last update: Rybáčková Markéta (11.09.2023)
Syllabus -

1. Determination of unknown concentration of butyllithium solution – working under inert atmosphere using inert lines and septum techniques.

2. Birch reduction of o-xylene – working with low-boiling liquids, working at low temperature, determination of reaction conversion by NMR spectroscopy.

3. Reduction of a carboxylic acid ester – working with hydride reagents under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

4. Acylation of cyclohexanone - utilization of enamines in organic synthesis, working with Dean-Stark apparatus, vacuum distillation.

5. Horner-Wadsworth-Emmons reaction – working with sodium hydride under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

6. Negishi cross-coupling – working with organozinc reagents under inert atmosphere, column chromatography.

7. Photochemical oxidation of sulfides to sulfoxides – measurement of UV spectra, calculation of extinction coefficient, weighing on an analytical balance, analysis of the reaction mixture by HPLC.

8. Ring-closing metathesis – working in a glovebox, kinetic study using NMR spectroscopy.

9. Microwave heating in organic synthesis - working with a microwave reactor, identification of an unknown sample.

10. Introduction into separation techniques in organic synthesis - separation of a product mixture via flash chromatography.

Last update: Rybáčková Markéta (11.09.2023)
Registration requirements -


Last update: Kundrát Ondřej (08.01.2018)
Course completion requirements -

Defense of an individual project.

Last update: Rybáčková Markéta (06.08.2019)
Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0.5 14
Účast v laboratořích (na exkurzi nebo praxi) 5 140
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1.5 42
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