SubjectsSubjects(version: 902)
Course, academic year 2022/2023
  
Specialized Laboratory - N110032
Title: Laboratoř oboru
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: winter
Points: winter s.:7
E-Credits: winter s.:7
Examination process: winter s.:
Hours per week, examination: winter s.:0/10 [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Guarantor: Kvíčala Jaroslav prof. Ing. CSc.
Rybáčková Markéta Ing. Ph.D.
Is interchangeable with: M110010
Examination dates   Schedule   
Annotation -
Last update: Kvíčala Jaroslav prof. Ing. CSc. (22.08.2013)
The students will learn modern laboratory techniques in both theoretical and practical way. The course will concentrate on advanced glass-blowing techniques, work under inert atmosphere using simple inert lines and septum techniques, work at low temperature, work under pressure in glass ampules, hydrogenation and work with low-boiling liquids and gases. The products obtained will be isolated by advanced separation techniques (microdistillation, column chromatography) and their structure and purity will be determined by selected analytical methods (NMR spectroscopy, TLC, UV/VIS spectroscopy). Significant part of the course is devoted to the work on research project in the laboratory of student's tutor.
Aim of the course -
Last update: Cibulka Radek prof. Ing. Ph.D. (22.08.2013)

Students will be able to:

use advanced glass-blowing techniques

perform the experiments at low temperature under inert conditions using inert lines and septum techniques

perform the experiments in sealed ampules

perform the experiments with low-boiling liquids under inert conditions

Literature -
Last update: Cibulka Radek prof. Ing. Ph.D. (28.08.2013)

R. Jaroslav Kvíčala: Laboratorní technika organické chemie, VŠCHT Praha, Praha 2007. ISBN10: 8070803223, ISBN13: 9788070803223.

Learning resources -
Last update: Kvíčala Jaroslav prof. Ing. CSc. (22.08.2013)

Printed experiment details

Teaching methods - Czech
Last update: Cibulka Radek prof. Ing. Ph.D. (24.08.2012)

V rámci tohoto předmětu posluchači absolvují týdenní kurz laboratorní techniky (organizováno turnusově Po-Pá 8:00 � 17:00, celkem 45 hodin). Další náplní kurzu je práce ve specializovaných laboratořích a literární rešerše (8 hodin týdně � 12 týdnů). Organizaci specializovaných laboratoří si studenti dohodnou s vedoucím práce.

Syllabus -
Last update: Kvíčala Jaroslav prof. Ing. CSc. (22.08.2013)

1. Advanced glass-blowing techniques, making Schlenk flask.

2. Protecting of propargyl alcohol with dihydropyran, control of purity of the product by NMR spectroscopy.

3. Alkylation of protected propargyl alcohol with unknown alkyl iodide,identification of the product by NMR spectroscopy.

4. Deprotection of protected alkynyl alcohol, control of purity of the product by NMR spectroscopy.

5. Determination of unknown concentration of butyllithium.

6. Work under low temperature, synthesis of unknown kinetic silyl enol ether, isolation of the product by microdistillation, identification of the product by NMR spectroscooy.

7. Work in sealed ampules, synthesis of unknown thermodynamic silyl enol ether, isolation of the product by microdistillation, identification of the product by NMR spectroscooy.

8. Katalytic hydrogenation of alkynol to cis-alkenol.

9. Work with low-boiling liquds, reduction of alkynol with sodium in liquid ammonia.

10. Work on the research project in the tutor laboratory.

Registration requirements -
Last update: Kvíčala Jaroslav prof. Ing. CSc. (22.08.2013)

Organic Chemistry II, Laboratory of Organic Chemistry I

Teaching methods
Activity Credits Hours
Účast v laboratořích (na exkurzi nebo praxi) 5 140
Obhajoba individuálního projektu 0,1 2
Práce na individuálním projektu 1,9 54
7 / 7 196 / 196
Coursework assessment
Form Significance
Regular attendance 20
Report from individual projects 20
Defense of an individual project 60

 
VŠCHT Praha