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The course deals with molecular mechanisms of host-pathogen interactions. Upon recapitulation of the basic
mechanisms of mammalian immune system function, the lectures will focus on genetic basis and regulation
mechanisms underlying virulence of bacterial pathogens. Molecular details of action of major virulence factors,
such as adhesins, toxins, complement resistance and immunomodulatory substances will be discussed. Action of
virulence factors will be discussed from the systemic context of the entire host organism down to the level of
biology and physiology of cells of the immune system. Principles of host-pathogen interactions will then be
analyzed using selected examples of major human pathogens and bacterial infections.
Last update: Hladíková Jana (13.12.2017)
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Z: Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, Malcolm E. Winkler: Bacterial Pathogenesis: A Molecular Approach, 3rd edition 2010 ASM Press, ISBN-13: 978-0632037759 Z:Kenneth Murphy, Casey Weaver: Janeway's Immunobiology, Ninth Edition (Immunobiology: The Immune System (Janeway), 2017, Garland Science, ISBN-13: 978-0815345053 D:Goering R., Dockrell H., Roitt I., et al.: Mims' Medical Microbiology, 2012, ELSEVIER, ISBN 9780808924401, 9780702056635. Last update: Šebo Peter (19.01.2018)
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1. Molecular mechanisms of anti-infectious immunity 2. Classes and mechanisms of action of bacterial virulence factors 3. Genetic equipment and gene expression regulation of bacterial pathogens 4. Experimental/animal systems for identification of virulence genes and for analysis of host-pathogen interactions 5. Protective mechanisms enabling bacteria to overcome innate and fool adaptive immunity 6. Cell biology and mechanisms of bacterial toxin action, intracellular bacterial pathogens 7. Vaccines as tools for protection from infection, modulation of host response and immunotherapy 8. Antibiotics as anti-infectious therapeutics and resistance to antibiotics 9. Intestinal microflora, commensals - the human microbiome 10. Most studied bacterial pathogens - an introductory overview: Corynebacterium diphteriae, Streptococcus pyogenes a Staphylococcus aureus 11. Most studied bacterial pathogens: Clostridium botulinum/perfringens/tetani, B. cereus, Helicobacter pylori 12. Most studied bacterial pathogens: Ricketsia, Fracisella, Coxiella, Yersinia, Salmonella, Shigella, 13. Most studied bacterial pathogens: Campylobacter jejuni, Vibrio cholerae, Escherichia coli - EPEC, ETEC, UPEC, NMEC 14. Most studied bacterial pathogens: Bordetella, Mycobacterium, Neisseria, Listeria, Borelia, Mycoplasma, Chlamydia Last update: Šebo Peter (19.01.2018)
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http://l125lsx.mbu.cas.cz/Lab125/index.php/component/jdownloads/category/2-bacterial-pathogenesis?Itemid=479 Last update: Šebo Peter (22.01.2018)
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Students will be able to:
Last update: Hladíková Jana (13.12.2017)
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Biochemistry, Microbiology and Molecular biology Last update: Šebo Peter (30.01.2018)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Obhajoba individuálního projektu | 0.7 | 20 | ||
Účast na přednáškách | 1 | 28 | ||
Práce na individuálním projektu | 0.6 | 16 | ||
Příprava na zkoušku a její absolvování | 0.7 | 20 | ||
3 / 3 | 84 / 84 |