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The course focuses on understanding and quantitative description of biological processes in the context of their implementation under defined conditions enabling to achieve reproducibility of results. The syllabus is based on the principles of kinetics, balancing as well as measurement and regulation of biological processes, including the design of the equipment.
Last update: TAJ320 (11.12.2013)
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Students will be able to: Understand the biological, chemical and engineering processes in the biotechnology industry Describe and evaluate basic biocatalytic processes. Quantitatively evaluate experimental data of processes catalyzed by biological elements and to carry out heat and mass balances of biotechnological processes. Design mixing and aeration equipment of bioreactors. Last update: Brányik Tomáš (22.08.2013)
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R: Doran P.M.: Bioprocess Engineering Principles, Academic, London, 1995, ISBN: 9780122208553 R: Moo-Young M.: Comprehensive biotechnology, Elsevier B.V., 2011, ISBN: 9780080885049 A: Dunn I.J. et al.: Biological Reaction Engineering, Wiley-VCH, 2003, ISBN:9783527307593 A: Najafpour G.D.: Biochemical Engineering and Biotechnology, Elsevier B.V., 2007, ISBN 9780444528452 Last update: Brányik Tomáš (22.08.2013)
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1. Engineering aspects of biotechnological processes 2. The structure of bioprocesses, overview of equipment and unit operations 3. Bioreactors - characteristics and types, methods of cultivation 4. Mixing in bioreactors - theory, power consumption, homogenization, shear stress 5. Hydrodynamic flow characteristics - retention time distribution, models of flow 6. Mass transfer - oxygen transfer, aeration methods, measurement and quantification, KLa 7. Heat transfer, heat balance of bioreactor, sterilization, cooling and heating 8. Engineering kinetics of chemical and enzymatic reactions 9. Kinetics of cell growth - mass balance, yield, metabolic quotient, inhibition, productivity 10. Cell culture methods - batch and fed batch cultivation 11. Cell culture methods - continuous culture 12. Scale-up and scale-down of bioprocesses 13. Measurement, control and modeling of biological processes 14. Design and construction of bioreactors, SIP and CIP systems Last update: Brányik Tomáš (22.08.2013)
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http://eso.vscht.cz Last update: Brányik Tomáš (22.08.2013)
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Chemical engineering, Microbiology Last update: Brányik Tomáš (22.08.2013)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.4 | 11 | ||
Obhajoba individuálního projektu | 0.1 | 3 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.4 | 11 | ||
Práce na individuálním projektu | 0.5 | 14 | ||
Příprava na zkoušku a její absolvování | 0.6 | 17 | ||
3 / 3 | 84 / 84 |
Coursework assessment | |
Form | Significance |
Regular attendance | 10 |
Report from individual projects | 10 |
Examination test | 20 |
Oral examination | 60 |