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The course focuses on understanding and quantitative description of biological processes in the context of their implementation under defined conditions enabling to achieve reproducibility of results. The syllabus is based on the principles of kinetics, balancing as well as measurement and regulation of biological processes, including the design of the equipment.
Last update: Kubová Petra (03.10.2018)
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Students will be able to:
Understand the biological, chemical and engineering processes in the biotechnology industry
Describe and evaluate basic biocatalytic processes.
Quantitatively evaluate experimental data of processes catalyzed by biological elements and to carry out heat and mass balances of biotechnological processes.
Design mixing and aeration equipment of bioreactors. Last update: Kubová Petra (03.10.2018)
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R: Doran P.M.: Bioprocess Engineering Principles, Academic, London, 1995, ISBN: 9780122208553
R: Moo-Young M.: Comprehensive biotechnology, Elsevier B.V., 2011, ISBN: 9780080885049
A: Dunn I.J. et al.: Biological Reaction Engineering, Wiley-VCH, 2003, ISBN:9783527307593
A: Najafpour G.D.: Biochemical Engineering and Biotechnology, Elsevier B.V., 2007, ISBN 9780444528452 Last update: Kubová Petra (03.10.2018)
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1. The issue of biotechnology and bioengineering.
2. The structure of bioprocess, equipment overview and unit operations.
3. Methods of optimization and modeling of biological processes.
4. Engineering kinetics of chemical and enzymatic reactions, kinetics of microbial growth.
5. Cultivation of microorganisms - batch and fed-batch cell cultures.
6. Cultivation of microorganisms - semicontinuous and continuous cell cultures.
7. Characteristics of phase folw - residence time distribution, flow models.
8. Mass transfer - oxygen transfer, aeration, measurement and quantification of KLa.
9. Specific aspects of plant/tissue cell and phototrophic cell cultivation.
10. Engineering aspects of enzyme and cell immobilization, biocatalysis.
11. Mixing in bioreactors - theory, power consumption, homogenization, shear forces.
12. Heat transfer, energy balance of bioreactors, sterilization, cooling and heating.
13. Scale-up of bioprocesses.
14. Construction materials, corrosion, design and construction of biotechnological processes. Last update: Kubová Petra (03.10.2018)
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http://eso.vscht.cz/predmety/N319008/ Last update: Kubová Petra (03.10.2018)
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