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The course is building on the basic knowledge of chemical engineering by the student and develops applications in bioengineering. Basic approaches including mass and energy balances, transport processes and reaction kinetics are synthesized to provide quantitative description of processes used in bioengineering. Special attention is given to reaction-transport processes in enzyme reactors and reactors with living cultures of microorganisms.
Last update: Kubová Petra (22.01.2018)
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Student must pass two tests during the course of semester (minimum 25 points out of 50 for each test). Last update: Schreiber Igor (30.05.2019)
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R: Shuler M. L. , Kargi F., DeLisa M., Bioprocess Engineering: Basic Concepts, 3rd Edition, Prentice Hall 2017, ISBN-13: 9780132901451 A: Doran P., Bioprocess Engineering Principles - 2nd Edition, Academic press 2012, ISBN: 9780122208515, 9780080917702 A: Villadsen J., Lee S.Y., Nielsen J., Stephanopoulos G. (eds.), Fundamental Bioengineering, Wiley-Blackwell, 2016, ISBN: 978-3527336746. Last update: Schreiber Igor (12.11.2018)
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1. Enzyme catalysis, thermodynamics of enzyme reactions, limitin cases 2. Enzyme reactors, mathematical models and their analysis 3. Immobilized enzymes, effects of mass transport 4. Effectiveness factor, Damköhler number, analysis of heterogeneous enz. systems 5. Microbial growth, stoichiometry of growth, product formation 6. Growth in batch systems 7. Growth in continual systems 8. Structured vs unstructured models of growth 9. Construction and operation of some fermentor types 10. Stirring and aeration 11. Mixed microbial cultures and their interaction 12. Chemostat dynamics with mixed cultures 13. Operating conditions, scale-up 14. Metabolic engineering, metabolic networks Last update: Kubová Petra (22.01.2018)
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lecture notes available at www.vscht.cz/uchi Last update: Kubová Petra (22.01.2018)
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Students will be able to: apply quantitative approaches of chemical engineering to biosystems design basic types of enzyme reactors and bioreactors design suitable unit operations for modification of inlets and outles from the bioreactor Last update: Kubová Petra (22.01.2018)
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Unit operations of chemical engineering I and II Last update: Kubová Petra (22.01.2018)
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| Teaching methods | ||||
| Activity | Credits | Hours | ||
| Účast na přednáškách | 1 | 28 | ||
| Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 1.5 | 42 | ||
| Příprava na zkoušku a její absolvování | 1 | 28 | ||
| Účast na seminářích | 0.5 | 14 | ||
| 4 / 4 | 112 / 112 | |||
| Coursework assessment | |
| Form | Significance |
| Continuous assessment of study performance and course -credit tests | 50 |
| Oral examination | 50 |