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Biotechnology in Chemical and Pharmaceutical Industry - M319017

Title:	Biotechnologie v chemické a farmaceutické výrobě
Guaranteed by:	Department of Biotechnology (319)
Faculty:	Faculty of Food and Biochemical Technology
Actual:	from 2020 to 2025
Semester:	winter
Points:	winter s.:5
E-Credits:	winter s.:5
Examination process:	winter s.:
Hours per week, examination:	winter s.:2/2, C+Ex [HT]
Capacity:	unlimited / unlimited (unknown)
Min. number of students:	unlimited
Qualifications:
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Level:
Note:	course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	Masák Jan prof. Ing. CSc.
Interchangeability :	N319035

Examination dates

This subject contains the following additional online materials

E-learning course

Annotation -

Chemical and pharmaceutical industry extends the use of biotechnological processes for obtaining new compounds or for reducing costs and environmental impact of the production of current compounds. Introductory lectures will provide detailed information about the current range of implementation of biotechnological processes in these industries. Attention is also given to explain the procedures for development of industrial strains achieving the high production of required compounds and then the specific features of the unit operations up-stream and down-stream processes for different types of biotechnology are discussed. The various types of processes are then discussed using examples of production of particular substances applied in the chemical and pharmaceutical industries. Special attention is paid to biotransformation processes. In the seminar, students work out individual theme the output of which is the design of a biotechnological process for the production of a selected substance.

Last update: Masák Jan (26.04.2025)

Course completion requirements -

Course credit based on the presentation of the seminar paper.

Oral exam.

Last update: Masák Jan (26.04.2025)

Literature -

Recommended:

Moo-Young, M. Comprehensive Biotechnology (2nd ed.). Amsterdam: Elsevier, 2011, s. ISBN 9780080885049.

Rehm,H.-J.,Reed G.. Biotechnology, 12 Vols., 2nd Ed. Weinheim: Wiley, 2008, s. ISBN 9783527620821.

Flickinger, M.C.. Encyclopedia of Bioprocess Technology. : Wiley, 2008, s. ISBN 9780471250586.

Ho, R.J.Y. Biotechnology and Biopharmaceuticals. : Wiley, 2003, s. ISBN 0471206903.

Verma, P. Industrial Microbiology and

Biotechnology

Emerging concepts in Microbial Technology. Singapore: Springer, 2023, 975 s. ISBN 978-981-97-6269-9.

Crommelin, D.J.A.,

Sindelar, R.D.,

Meibohm, B.. Pharmaceutical Biotechnology

Fundamentals and Applications. New York: Springer, 2013, 551 s. ISBN 978-1-4614-6485-3.

Last update: Masák Jan (26.04.2025)

Teaching methods - Czech

Last update: Masák Jan (26.04.2025)

Requirements to the exam -

Preparation and defense of the seminar paper.

Last update: Masák Jan (26.04.2025)

Syllabus -

1. Introduction - the status of biotechnology in the chemical and pharmaceutical industry

2. Characteristics of biotechnological processes

3. The development of industrial strains - physiological adaptation, gene modification, transformation of higher organisms

4. Biotechnological production of primary and secondary metabolites - unit operations, process management, economic balance

5. Biotechnological production of biopharmaceuticals - characteristics of the processes

6. Biotransformation - basic characteristics of the processes

7. Biotransformation - examples

8. Antibiotics - characteristics, production organisms, technological processes

9. Antibiotics - the current state of world production, research and development

10. Cancerostatics - characteristics, production organisms, technological processes

11. Alkaloids - characteristics, production organisms, technological processes

12. Vitamins - characteristics, production organisms, technological processes

13. Enzymes - characteristics, production organisms, technological processes

14. Polysaccharides - characteristics, production organisms, technological processes

Last update: Masák Jan (26.04.2025)

Learning outcomes -

Students will be able to:

select appropriate procedures for the preparation of industrial biological agents (microorganisms, enzymes, plant or animal tissue culture);

generally suggest biotechnological process for the production a substance;

evaluate the process, health and economic risks of a particular biotechnology;

apply extensive knowledge in the design of biotechnological processes in the chemical and biotechnology industries

Last update: Masák Jan (26.04.2025)

Teaching methods
	Activity	Credits	Hours
	Účast na přednáškách	2	56
	Práce na individuálním projektu	1	28
	Příprava na zkoušku a její absolvování	2	56
		5 / 5	140 / 140