SubjectsSubjects(version: 954)
Course, academic year 2023/2024
Toxicology and Ecotoxicology I - AB240001
Title: Toxicology and Ecotoxicology I
Guaranteed by: Department of Environmental Chemistry (240)
Faculty: Faculty of Environmental Technology
Actual: from 2023
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Additional information: http://Předmět je vyučován pouze v zimním semestru. Zkoušky se konají u přednášejících.
Old code: ZTOE
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: McGachy Lenka Ing. Ph.D.
Vyskočilová Eliška doc. Ing. Ph.D.
Himl Michal Ing. Ph.D.
Interchangeability : N111009, N240011, S111009, Z240011
This subject contains the following additional online materials
Annotation -
Toxicology deals with the interaction of chemicals and the living organism. It is the subject of a summary of basic information on substances that damage the living organism. The subject acquaints with the fate of the substances in the organism and their effects on them and with the way of their toxicity. Several lectures focus on selected inorganic and organic toxic substances and some of their groups. One lecture introduces the prevention of accidents, principles of safe work with toxic substances, describes firefighting and first aid bases. Other lectures briefly describe the environment, the flow of substances and energy in it. The final lectures follow up on the topic of toxic substances in the environment and the problems associated with them.
Last update: Kubová Petra (06.03.2019)
Aim of the course -

Students will be able to understand:

  • The basic survey about toxicity and negative influence of certain chemical materials on human organism
  • The fate of xenobiotics in organism: entrance, distribution, biotransformation, excretion
  • The safe disposal with chemical substances and principles of first aid during accidents in chemical laboratory
Last update: Kubová Petra (06.03.2019)
Literature -

I. Linhart: Basic Terms in Toxicology, Ecology and Ecotoxicology (A bilingual textbook). UCT Press, UCT Prague 2019.


S. Kacew and B.-M-Lee, editors: Lu's Basic Toxicology. Fundamentals, Target Organs, and Risk Assessment. 6th edition, CRC Press 2012; ISBN: 13:978-1-841849539; 10:978-1-841849537); Chapters 1 - 4, 7, 20, 23 and 24.

S. E. Manahan: Toxicological Chemistry and Biochemistry. 3rd edition, Lewis Publishers 2003; ISBN:1-56670-618-1

S.E. Manahan: Fundamentals of Environmental and Toxicological Chemistry. 4th edition, CRC Press 2013;978-1-4665-5316-3

Gilbert Steven G.: A Small Dose of Toxicology, The Health Effects of Common Chemicals, Informa Healthcare USA, 2008, ISBN-10: 0-4153-1168-3, ISBN-13: 978-0-4153-1168-7

Last update: Linhart Igor (10.09.2020)
Learning resources -

Last update: Kubová Petra (06.03.2019)
Syllabus -

1. Introduction, structure of the subject, history of toxicology, ecotoxicology and ecology, concepts and definitions.

2. Substances versus organism - Uptake of xenobiotics, barriers to the uptake, input, absorption, distribution.

3. Biotransformation of xenobiotics, examples of biotransformation reactions of toxic substances.

4. Effects of xenobiotics, types and mechanisms of effects.

5. Assessment of toxicity, literature sources and experimental procedures.

6. Regulation of work with chemicals and MSDS.

7. Toxicity, ecotoxicity and hazards of inorganic substances.

8. Toxicity, ecotoxicity and hazards of organic substances.

9. Abuse of chemical substances: chemical warfare agents and addictive substances.

10. Safety at chemical workplaces (main hazards and ways to minimize the risk).

11. Abiotic and biotic components of the global ecosystem.

12. Biogeochemical cycles and strams energy in nature.

13. Toxic substances in the environment.

14. Current environmental problems.

Last update: Linhart Igor (10.09.2020)
Registration requirements -


Last update: Kubová Petra (06.03.2019)
Course completion requirements -

Written Exam:

• Students enrol in SIS.

• To complete the course students, have to pass written exam with minimum score of 50%.

Last update: McGachy Lenka (08.09.2023)