Students will be able to:

understand approaches to suggest suitable target

understand principles of basic computational approaches for drug design

understand approaches to develop leading structure

know modern approaches for drug discovery.

Students will be able to:

understand approaches to suggest suitable target

understand principles of basic computational approaches for drug design

understand approaches to develop leading structure

know modern approaches for drug discovery.

Z: K. Stromgaard, P. Krogsgaard-Larsen, U. Madsen (Eds.): Textbook of Drug Design and Discovery, CRC Press, 5th Edition 2016; ISBN 9781032339948

Z: R. B. Silverman, M. W. Holladay: The Organic Chemistry of Drug Design and Drug Action, Academic Press 2014; ISBN 978-0-12-382030-3

D: C. Rostron: Drug Design and Development, Oxford 2020; ISBN: 9780198749318

R:K. Stromgaard, P. Krogsgaard-Larsen, U. Madsen (Eds.): Textbook of Drug Design and Discovery, CRC Press, 5th Edition 2016; ISBN 9781032339948

R:R. B. Silverman, M. W. Holladay: The Organic Chemistry of Drug Design and Drug Action, Academic Press 2014; ISBN 978-0-12-382030-3

A: C. Rostron: Drug Design and Development, Oxford 2020; ISBN: 9780198749318

xxx

xxx

1. The Drug Design and Discovery process

2. Selecting the right target

3. How drugs work

4. Computer-aided drug design I: Structure-Based Drug Design

5. Computer-aided drug design I: Ligand-Based Drug Design

6. Natural compounds in Drug Discovery

7. Fragment-Based Drug Design

8. Hit discovery and lead optimisation I: Structure-Activity Relationships

9. Hit discovery and lead optimisation II: Hit-to-Lead

10. Hit discovery and lead optimisation III: Lead Optimisation

11. Prodrugs

12. Recent advances in Drug Design and Medicinal Chemistry

13. Drugs and their therapeutic landscape

14. Decision making in Drug Discovery

1. The Drug Design and Discovery process

2. Selecting the right target

3. How drugs work

4. Computer-aided drug design I: Structure-Based Drug Design

5. Computer-aided drug design I: Ligand-Based Drug Design

6. Natural compounds in Drug Discovery

7. Fragment-Based Drug Design

8. Hit discovery and lead optimisation I: Structure-Activity Relationships

9. Hit discovery and lead optimisation II: Hit-to-Lead

10. Hit discovery and lead optimisation III: Lead Optimisation

11. Prodrugs

12. Recent advances in Drug Design and Medicinal Chemistry

13. Drugs and their therapeutic landscape

14. Decision making in Drug Discovery

Úspěšné absolvování zkouškové písemky.

It is compulsory to pass written examination test.