Studenti budou umět:

Detailně interpretovat 1D a 2D NMR spektra (zejména 1H, 19F, 13C, 31P, 15N, APT, HOMODEC, NOE, NOEDIF, NOESY1D, 2D NOESY, 2D HMBC, 2D HSQC, 2D COSY, 2D TOCSY, ...), a na základě jejich kombinace jednoznačně přiřadit signály daným atomům v molekule, či navrhnout strukturu neznámé látky.

Students will be able to:

In detail interpret 1D and 2D NMR spectra (in particular 1H, 19F, 13C, 31P, 15N, APT, HOMODEC, NOE, NOEDIF, NOESY1D, 2D NOESY, 2D HMBC, 2D HSQC, 2D COSY, 2D TOCSY, ...), and based on a combination of the uniquely assign signals to the atoms in the molecule, or to propose a structure of unknown substance.

D:

Holík: Čtyři lekce z NMR, Univerzita J. E. Purkyně, 1987

Hollerton: Essential Practical NMR for Organic Chemistry, Kindle Edition, 2011.

A: Holík: Čtyři lekce z NMR, Univerzita J. E. Purkyně, 1987

A: Hollerton: Essential Practical NMR for Organic Chemistry, Kindle Edition, 2011.

Web: http://www.vscht.cz/anl/dolensky/technmr/index.html

Web: http://www.vscht.cz/anl/dolensky/technmr/index.html

Přednášky

Lessons

1. NMR spectrometer, the origin of NMR signal, the basic parameters of the NMR spectra

2. Chemical and magnetic equivalency of cores, dynamic NMR

3. The multiplicity of signals, interaction 1H-1H

4. Techniques for the measurement and interpretation of 1H NMR spectra

5. Homonuclear decoupling, J-resolved, COSY, LR COSY and TOCSY

6. Nuclear Overhauser effect, NOEDIF, 1D and 2D NOESY, ROESY

7. Heteronuclear interactions, 1H, 13C, 31P, 19F, 2H and 15N

8. 13C NMR spectra, isotopomers

9. Techniques for the measurement and interpretation of the 13C NMR spectra, 1H decoupling, ATP, DEPT

10. Measurement and interpretation of 2D 1H-13C gHSQC

11. Measurement and interpretation of 2D 1H-13C gHMBC

12. Superposition information from NMR experiments

13. Interpretation of spectra of known substances, prediction of NMR spectra

14. Identification of unknown substances from NMR spectra

Znalost základních vztahů mezi strukturou organické látky a jejím 1H a 13C NMR spektry.

Knowledge of the fundamental relationships between the structure of organic compounds and its 1H and 13C NMR spectra.